MAOA: Enzyme Involved in Neurotransmitter Metabolism and Neurological Disorders

Target Name: MAOA

NCBI ID: G4128

MAOA

MAOA: Enzyme Involved in Neurotransmitter Metabolism and Neurological Disorders

MAOA (Monoamine oxidase A (MAO-A)) is a enzyme that is involved in the metabolism of neurotransmitters, such as dopamine, serotonin, and norepinephrine. It is a critical enzyme in the brain and has been implicated in the treatment of various neurological disorders.

One of the main functions of MAOA is the breaking down of neurotransmitters, which is critical for the transmission of signals in the brain. MAOA is involved in the conversion of neurotransmitters to their active forms, which are then either excreted from the brain or used to transmit signals.

The MAOA enzyme has been shown to be involved in the development and progression of several neurological disorders, including Parkinson's disease, addiction, and depression. In addition, MAOA has also been implicated in the treatment of addiction and depression.

One of the reasons for the involvement of MAOA in these disorders is its role in the production of neurotransmitters. In particular, MAOA has been shown to play a role in the production of dopamine, which is a neurotransmitter that is involved in motor control and mood regulation.

In addition to its role in neurotransmitter production, MAOA is also involved in the regulation of neurotransmitter levels. This is important for maintaining the homeostasis of the brain and for the proper functioning of the nervous system.

Another important function of MAOA is its role in the detoxification of neurotransmitters. This is important for protecting the brain from the harmful effects of neurotransmitters and for maintaining the health and function of the nervous system.

In conclusion, MAOA is an important enzyme that is involved in the metabolism of neurotransmitters and has been implicated in the development and progression of several neurological disorders. As a potential drug target, MAOA is a promising target for the development of new treatments for addiction, depression, and other neurological disorders.

Protein Name: Monoamine Oxidase A

Functions: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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