EXOSC5: A Protein Involved in Various Diseases and Its Potential as A Drug Target

Target Name: EXOSC5

NCBI ID: G56915

EXOSC5

EXOSC5: A Protein Involved in Various Diseases and Its Potential as A Drug Target

EXOSC5 (EXOS5_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and muscle. It is a key regulator of the cytoskeleton, which is the structure that gives cells their shape and provides support. EXOSC5 is also involved in cell signaling and has been linked to a number of diseases, including cancer.

As a drug target, EXOSC5 is an attractive target for researchers because of its role in various diseases and its potential to be modified to become a therapeutic agent. Studies have shown that inhibiting EXOSC5 has potential to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key challenges in studying EXOSC5 is its complex structure. EXOSC5 is a transmembrane protein that is involved in the cytoskeleton, which is a structure that is located inside the cell membrane. This makes it difficult to study because it is not easily accessible. However, researchers have been able to study its effects by using various techniques, such as knockdown mice and cell-based assays.

In addition to its role in the cytoskeleton, EXOSC5 is also involved in cell signaling. It has been shown to be involved in a number of signaling pathways, including the TGF-β pathway, which is involved in cell growth and differentiation. This makes it a potential target for drugs that are designed to treat diseases that are caused by changes in cell signaling pathways.

EXOSC5 has also been linked to a number of diseases, including cancer. Studies have shown that high levels of EXOSC5 are associated with an increased risk of certain types of cancer, such as breast and ovarian cancer. This suggests that targeting EXOSC5 may be a promising way to treat these diseases.

Another potential use of EXOSC5 is as a biomarker. By measuring the levels of EXOSC5 in cancer cells, researchers can determine the effectiveness of different treatments. This can be a valuable tool for understanding how different treatments affect cancer cells and how they may be used to treat cancer.

In conclusion, EXOSC5 is a protein that is expressed in various tissues of the human body and is involved in the cytoskeleton and cell signaling. Its complex structure and involvement in various diseases make it an attractive target for researchers. Further studies are needed to fully understand its role and potential as a drug target and biomarker.

Protein Name: Exosome Component 5

Functions: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes

The "EXOSC5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EXOSC5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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