EXOSC8: The Potential Drug Target and Biomarker (G11340)

Target Name: EXOSC8

NCBI ID: G11340

EXOSC8

Other Name(s): Exosome component 8 | OIP-2 | RP11-421P11.3 | OIP2 | p9 | EAP2 | Ribosomal RNA-processing protein 43 | Rrp43p | CBP-interacting protein 3 | CIP3 | RRP43 | exosome component 8 | Opa interacting protein 2 | EXOS8_HUMAN | PCH1C | Exosome complex component RRP43 | ribosomal RNA-processing protein 43 | BA421P11.3 | exosome complex exonuclease RRP43 | Opa-interacting protein 2 | bA421P11.3 | Exosome complex exonuclease RRP43

EXOSC8: The Potential Drug Target and Biomarker

Exosome component 8 (EXOSC8) is a protein that is expressed in various tissues and organs, including the brain, pancreas, and gastrointestinal tract. Its primary function is to help regulate the formation and maintenance of exosomes, which are small structures that contain a combination of genetic material, proteins, and other bioactive molecules.

Recent studies have shed light on the potential role of EXOSC8 as a drug target and biomarker. In this article, we will explore the biology and function of EXOSC8, as well as its potential as a drug target and biomarker.

The biology of EXOSC8

EXOSC8 is a 21-kDa protein that is expressed in various tissues and organs, including the brain, pancreas, and gastrointestinal tract. It is composed of a unique arrangement of transmembrane and cytoplasmic domains that give it its unique structure and function.

The N-terminus of EXOSC8 is rich in multiple coiled-coil regions, which are known to play a critical role in the protein's stability and functions. The C-terminus of EXOSC8 contains a unique N-terminal extension that is rich in multiple putative nuclear localization domains (PLDNs) and is involved in the protein's nuclear import and retention.

EXOSC8 functions as a negative regulator of exosome formation by promoting the dissociation of exosome-associated proteins (EAPs) from the exosome membrane and preventing their recombination with the exosome protein (ESP). This process is critical for maintaining the integrity and stability of exosomes, which are involved in various cellular processes, including intracellular signaling, protein delivery, and intracellular waste clearance.

In addition to its role in exosome regulation, EXOSC8 is also involved in the regulation of cell adhesion, migration, and invasion. It has been shown to play a critical role in the regulation of PDGF signaling, which is involved in the development, maintenance, and treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

The potential drug target of EXOSC8

The potential drug target of EXOSC8 is its role in the regulation of exosome formation and maintenance. By targeting EXOSC8, researchers may be able to develop new treatments for various diseases that are characterized by the dysfunction of exosomes.

One of the key challenges in developing new treatments for exosome-related diseases is the difficulty of targeting the underlying molecular mechanisms that are responsible for their development. This is because many exosome-related diseases are complex and involve the participation of multiple proteins and other molecules. However, recent studies have identified several potential targets for EXOSC8 that may be able to help develop new treatments for various exosome-related diseases.

The first potential drug target for EXOSC8 is its role in the regulation of PDGF signaling. PDGF signaling is involved in the development, maintenance, and treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. EXOSC8 has been shown to play a critical role in the regulation of PDGF signaling, and targeting it may be able to lead to new treatments for these diseases.

Another potential drug target for EXOSC8 is its role in the regulation of exosome-associated protein (EAP) interactions. EAPs are proteins that are associated with exosomes and play a critical role in their formation and stability. EXOSC8 has been shown to promote the dissociation of EAPs from exosome membranes, which may

Protein Name: Exosome Component 8

Functions: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs

The "EXOSC8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EXOSC8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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