EXOSC4: A Drug Target / Disease Biomarker (G54512)

Target Name: EXOSC4

NCBI ID: G54512

EXOSC4

EXOSC4: A Drug Target / Disease Biomarker

EXOSC4, also known as exosome protein 4, is a protein that is expressed in various tissues and cells throughout the body. It is a member of the executon system, which is a complex protein transport system that helps to regulate the transfer of genetic information from the DNA to the ribosome during the process of protein synthesis.

Recent studies have suggested that EXOSC4 may have potential as a drug target or biomarker. The discovery of EXOSC4 as a drug target is of particular interest as it has been shown to play a role in the regulation of cellular processes that are important for cancer progression.

One of the key functions of EXOSC4 is its role in the regulation of the cytoskeleton. The cytoskeleton is the structure that gives shape to the cell and helps to maintain its shape and stability. EXOSC4 is involved in the regulation of the cytoskeleton by helping to maintain the integrity of the microtubules that make up the cytoskeleton.

Microtubules are made up of a protein called tau, which is involved in the regulation of many cellular processes. Studies have shown that EXOSC4 helps to protect tau from degradation and also helps to regulate the assembly and disassembly of microtubules. This suggests that EXOSC4 may be a useful drug target for diseases that are characterized by the accumulation of tau protein, such as Alzheimer's disease and other forms of neurodegenerative disease.

In addition to its role in the regulation of the cytoskeleton, EXOSC4 has also been shown to be involved in the regulation of many other cellular processes. For example, it has been shown to play a role in the regulation of cell adhesion, cell migration, and the distribution of intracellular signaling molecules.

The potential use of EXOSC4 as a biomarker is also of particular interest. The development of new diagnostic tests for cancer has been a major focus of recent years, and the discovery of EXOSC4 as a potential drug target or biomarker may provide a new tool for the diagnosis and treatment of cancer.

EXOSC4 has been shown to be expressed in a wide range of tissues and cells, including brain, spinal cord, and heart. This suggests that it may be a useful biomarker for a variety of diseases, including cancer. In addition, the fact that EXOSC4 is involved in the regulation of many cellular processes makes it a potential target for small molecules, which are often used as therapeutic agents.

The discovery of EXOSC4 as a potential drug target or biomarker is still in its early stages, and much more research is needed to fully understand its role in cellular processes and its potential as a therapeutic agent. However, the potential of EXOSC4 as a drug target or biomarker is of particular interest, and further studies are being conducted to investigate its potential in the development of new therapeutic agents for a variety of diseases.

Protein Name: Exosome Component 4

Functions: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC4 binds to ARE-containing RNAs

The "EXOSC4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about EXOSC4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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