VPS41: A Potential Drug Target and Biomarker (G27072)

Target Name: VPS41

NCBI ID: G27072

VPS41

VPS41: A Potential Drug Target and Biomarker

VPS41 (VPS41 variant 1) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidney. It is a member of the P-type cation transporter (PCT) family, which is a family of transmembrane proteins that play an important role in the regulation of ion transport and signaling.

The PCT family consists of four subfamilies, including PCT1, PCT2, PCT3, and PCT4. VPS41 is a member of the PCT3 subfamily, which is characterized by the presence of a unique transmembrane region that is composed of a single layer of phospholipids. This region is known as the transmembrane region (TMR) and is responsible for the regulation of ion transport and signaling.

VPS41 is a 21-kDa protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidney. It is primarily localized to the cytoplasm of cells and is not detected in the cell nucleus. VPS41 is a monomeric protein, which means that it is composed of a single polypeptide chain.

The PCT family plays an important role in the regulation of ion transport and signaling. The TMR is responsible for the regulation of the movement of positively charged ions (H+) and negatively charged ions (Na+) across the membrane. This region of the protein is known as the ANO1 (alpha-subunit taurine transporter 1) site and is located in the N-terminus region of the protein.

VPS41 is involved in many different cellular processes in the body. For example, it is involved in the regulation of cell signaling, as well as the regulation of ion transport and signaling. It is also involved in the regulation of cellular metabolism, as well as the regulation of cellular growth and differentiation.

VPS41 is a potential drug target (or biomarker) because of its involvement in many different cellular processes in the body. For example, because it is involved in the regulation of cell signaling, it may be a good target for drugs that are designed to disrupt signaling pathways. Because it is involved in the regulation of ion transport and signaling, it may be a good target for drugs that are designed to disrupt ion channels.

VPS41 is also a good candidate for a biomarker because of its expression in various tissues of the body. This makes it a potential candidate for use in diagnostic tests, such as cancer biomarkers or cardiovascular biomarkers.

In conclusion, VPS41 is a protein that is expressed in various tissues of the body and is involved in the regulation of many different cellular processes in the body. It is a member of the PCT family and is characterized by the presence of a unique transmembrane region that is responsible for the regulation of ion transport and signaling. As a result, VPS41 is a potential drug target (or biomarker) and may be useful in the development of new therapeutic approaches for a variety of diseases.

Protein Name: VPS41 Subunit Of HOPS Complex

Functions: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847, PubMed:21802320). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660)

The "VPS41 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about VPS41 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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