Target Name: GNB3
NCBI ID: G2784
Review Report on GNB3 Target / Biomarker Content of Review Report on GNB3 Target / Biomarker
GNB3
Other Name(s): Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3 | G protein subunit beta 3 | GTP-binding regulatory protein beta-3 chain | Hypertension associated protein | guanine nucleotide binding protein (G protein), beta polypeptide 3 | guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 | transducin beta chain 3 | CSNB1H | G protein subunit beta 3, transcript variant 1 | GBB3_HUMAN | hypertension associated protein | HG2D | heterotrimeric guanine nucleotide-binding protein 2D | GNB3 variant 1 | Transducin beta chain 3 | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (isoform 1) | G protein, beta-3 subunit

GNB3 Plays A Crucial Role in DNA Replication, Repair and Cell Signaling Pathways

Guanine nucleotide-binding proteins (GNPs) are a family of proteins that play a crucial role in various cellular processes, including DNA replication, transcription, and repair. GNPs are composed of four subunits, G(I), G(S), G(T), and G(尾), which function together to recognize and bind to specific DNA sequences.

Guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3 (GNBP-G(尾)) is a member of the GNBP family and is expressed in various tissues and cells. GNBP-G(尾) is a 21-kDa protein that contains a N-terminal transmembrane domain, a single beta-sheet, and a C-terminal tail. It has been shown to play a critical role in the regulation of DNA replication and repair, and is therefore a potential drug target or biomarker.

The N-terminal transmembrane domain of GNBP-G(尾) is rich in various ion channels, including Na+ and K+ channels. These channels allow the protein to conduct electrical signals across the membrane and to regulate the concentration of various ions in the cell. The single beta-sheet of GNBP-G(尾) contains four conserved acidic residues that form a basic region. This region is known to play a structural role in the protein's stability and functions as a binding site for various nucleotides.

The C-terminal tail of GNBP-G(尾) contains a conserved nucleotide-binding site (NBS) that is known to interact with DNA. The NBS is a critical region that interacts with the nucleotide base-pairing system and allows the protein to recognize specific DNA sequences. GNBP-G(尾) has been shown to bind to several DNA sequences with different affinity, including G-rich sequences and A-rich sequences.

GNNBP-G(尾) has been shown to play a critical role in the regulation of DNA replication and repair. In S. cerevisiae, GNBP-G(尾) was shown to be involved in the regulation of DNA replication by preventing the formation of a DNA double helix during the G1 phase of the cell cycle. In addition, the protein was shown to play a role in the regulation of DNA repair by promoting the formation of a stable single-stranded DNA molecule after a DNA double-strand break.

GNNBP-G(尾) has also been shown to be involved in the regulation of cell signaling pathways. For example, the protein has been shown to play a role in the regulation of the T-cell receptor (TCR) signaling pathway, which is critical for the development and function of T cells. In addition, GNBP-G(尾) has been shown to play a role in the regulation of the protein kinase B (PKB) signaling pathway, which is involved in various cellular processes including cell growth, differentiation, and survival.

GNNBP-G(尾) has also been shown to be involved in the regulation of cellular processes that are important for the development and progression of cancer. For example, the protein has been shown to play a role in the regulation of cell migration, which is critical for the development of cancer cells that can migrate to new environments and form tumors. In addition, GNBP-G(尾) has been shown to play a role in the regulation of the angiogenesis process, which is the process by which new blood vessels are formed in the body. This process is critical for the development of many types of cancer.

GNNBP-G(尾) has also been shown to be involved in the regulation of gene expression. For example, the protein has been shown to play a role in the regulation of the expression of the gene encoding

Protein Name: G Protein Subunit Beta 3

Functions: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

The "GNB3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GNB3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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GNB4 | GNB5 | GNE | GNG10 | GNG11 | GNG12 | GNG12-AS1 | GNG13 | GNG2 | GNG3 | GNG4 | GNG5 | GNG5P5 | GNG7 | GNG8 | GNGT1 | GNGT2 | GNL1 | GNL2 | GNL3 | GNL3L | GNLY | GNMT | GNPAT | GNPDA1 | GNPDA2 | GNPNAT1 | GNPTAB | GNPTG | GNRH1 | GNRH2 | GNRHR | GNRHR2 | GNS | GOLGA1 | GOLGA2 | GOLGA2P10 | GOLGA2P11 | GOLGA2P2Y | GOLGA2P5 | GOLGA2P7 | GOLGA3 | GOLGA4 | GOLGA5 | GOLGA6A | GOLGA6B | GOLGA6C | GOLGA6D | GOLGA6EP | GOLGA6FP | GOLGA6L1 | GOLGA6L10 | GOLGA6L2 | GOLGA6L22 | GOLGA6L3P | GOLGA6L4 | GOLGA6L5P | GOLGA6L6 | GOLGA6L9 | GOLGA7 | GOLGA7B | GOLGA8A | GOLGA8B | GOLGA8CP | GOLGA8DP | GOLGA8EP | GOLGA8F | GOLGA8G | GOLGA8H | GOLGA8IP | GOLGA8J | GOLGA8K | GOLGA8M | GOLGA8N | GOLGA8O | GOLGA8Q | GOLGA8R | GOLGA8S | GOLGA8UP | GOLGB1 | Golgi-associated retrograde protein (GARP) complex | GOLIM4 | GOLM1 | GOLM2 | GOLPH3 | GOLPH3L | GOLT1A | GOLT1B | GON4L | GON7 | GOPC | GORAB | GORASP1 | GORASP2 | GOSR1 | GOSR2 | GOT1 | GOT1-DT | GOT1L1 | GOT2