GNA11: A Protein Interaction and Pain Regulation Drug Target (G2767)

Target Name: GNA11

NCBI ID: G2767

GNA11

GNA11: A Protein Interaction and Pain Regulation Drug Target

GNA11 (Guanine Nucleotide-Binding Protein G(y) Subunit Alpha) is a protein that is expressed in various cell types of the human body, including neurons, muscle cells, and blood vessels. It is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a crucial role in cellular signaling.

GNA11 is a 21-kDa protein that is composed of 158 amino acid residues. It has a unique structure that consists of a transmembrane region, a cytoplasmic region, and an N-terminus region that is involved in protein-protein interactions.

One of the unique features of GNA11 is its ability to interact with guanine nucleotides, which are small nucleotides that play a crucial role in cellular signaling. GNA11 has been shown to interact with GTP, a key intracellular signaling molecule, and this interaction is involved in the regulation of various cellular processes, including cell signaling, cell division, and cell survival.

GNA11 has also been shown to play a role in the regulation of pain perception, which is a critical aspect of human physiology. Studies have shown that GNA11 is involved in the regulation of pain signaling, and that its expression is reduced in individuals with certain forms of pain.

In addition to its role in pain regulation, GNA11 has also been shown to be involved in the regulation of various other cellular processes, including cell signaling, cell division, and cell survival. For example, GNA11 has been shown to be involved in the regulation of cell proliferation, and in the regulation of cell apoptosis, which is the process by which cells die.

GNA11 has also been shown to play a role in the regulation of cardiovascular function, which is critical for maintaining the health and function of the cardiovascular system. Studies have shown that GNA11 is involved in the regulation of cardiac function, including the regulation of heart rate and the contraction of blood vessels.

GNA11 is also involved in the regulation of neurotransmitter signaling, which is critical for the communication between neurons and other cells in the nervous system. Studies have shown that GNA11 is involved in the regulation of the release of neurotransmitters, including dopamine and serotonin.

GNA11 has also been shown to play a role in the regulation of inflammation, which is a critical aspect of immune function. Studies have shown that GNA11 is involved in the regulation of the production of pro-inflammatory cytokines, which are involved in the regulation of inflammation.

GNA11 has also been shown to play a role in the regulation of the efficacy of various drugs, including chemotherapy drugs and anti-inflammatory drugs. Studies have shown that GNA11 is involved in the regulation of the efficacy of these drugs, and that its expression is reduced in individuals with certain forms of cancer.

GNA11 is also involved in the regulation of the regulation of various cellular processes, including cell signaling, cell division, and cell survival. Studies have shown that GNA11 is involved in the regulation of cell cycle progression, and that its expression is reduced in individuals with certain forms of cancer.

GNA11 has also been shown to play a role in the regulation of the efficacy of various drugs, including chemotherapy drugs and anti-inflammatory drugs. Studies have shown that GNA11 is involved in the regulation of the efficacy of these drugs, and that its expression is reduced in individuals with certain forms of cancer.

In conclusion, GNA11 is a protein that is involved in a wide range of cellular processes that are critical for maintaining the health and function of the human body. Its ability to interact with guanine nucleotides and its involvement in the regulation of various cellular processes make it an attractive drug target and a potential biomarker for a variety of diseases. Further research is needed to fully understand the role of GNA11 in cellular signaling and its potential as a drug target.

Protein Name: G Protein Subunit Alpha 11

Functions: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:31073061). Acts as an activator of phospholipase C (PubMed:31073061). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs) (PubMed:27852822). Together with GNAQ, required for heart development (By similarity)

The "GNA11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GNA11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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