GnBP5: A Potential Drug Target or Biomarker (G10681)

Target Name: GNB5

NCBI ID: G10681

GNB5

GnBP5: A Potential Drug Target or Biomarker

Guanine nucleotide-binding proteins (GNBPPs) are a family of proteins that play a crucial role in various cellular processes, including intracellular signaling, DNA replication, and cell survival. GnBP5, also known as GNP-尾5, is a GnBPP that is expressed in various tissues and cell types, including brain, heart, and pancreas. GnBP5 has been shown to play a critical role in the regulation of cellular processes, and it is a potential drug target or biomarker.

Expression and Localization

GnBP5 is a 120-kDa protein that is expressed in various tissues and cell types. It is predominantly expressed in the brain, where it is found in the cell cytoplasm and in the endoplasmic reticulum (ER). GnBP5 has also been shown to be expressed in other tissues, including heart and pancreas. GnBP5 is localized to the cytoplasm of the cells, where it can interact with various cellular signaling pathways.

Function

GnBP5 is involved in various cellular processes, including intracellular signaling, DNA replication, and cell survival. It has been shown to play a critical role in the regulation of cell proliferation, differentiation, and survival. GnBP5 has been shown to interact with various signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT.

GnBP5 has also been shown to play a critical role in the regulation of DNA replication. GnBP5 has been shown to interact with the DNA replication complex, which includes the protein DNA-binding protein (DNA-BP) and the enzyme DNA polymerase (DNA-PNP). GnBP5 has been shown to promote the recruitment of DNA-BP to the replication complex, which is necessary for the initiation of DNA replication.

In addition to its role in DNA replication, GnBP5 has also been shown to play a critical role in cell survival. GnBP5 has been shown to interact with various signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT. GnBP5 has been shown to promote the recruitment of cell survival signaling proteins, such as Bcl-2 and p53, to the endoplasmic reticulum (ER), which is necessary for the regulation of cell survival.

Drug Target or Biomarker

GnBP5 is a potential drug target or biomarker due to its involvement in various cellular processes. GnBP5 has been shown to interact with various signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT. GnBP5 has been shown to promote the recruitment of DNA-BP to the replication complex, which is necessary for the initiation of DNA replication. GnBP5 has also been shown to promote the recruitment of cell survival signaling proteins, such as Bcl-2 and p53, to the ER, which is necessary for the regulation of cell survival.

In addition to its potential as a drug target or biomarker, GnBP5 may also be a useful target for small molecule inhibitors. GnBP5 has been shown to interact with various signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT. Therefore, small molecule inhibitors that target these signaling pathways may be effective in the inhibition of GnBP5.

Conclusion

GnBP5 is a GnBPP that is involved in various cellular processes, including intracellular signaling, DNA replication, and cell survival. GnBP5 has been shown to play a critical role in the regulation of these processes, and it is a potential drug target or biomarker. Further research is needed to fully understand the role of GnBP5 in cellular processes and its potential as a drug target or biomarker.

Protein Name: G Protein Subunit Beta 5

Functions: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (PubMed:27677260). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity)

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•   expression level;
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