GNB2: A Drug Target and Potential Biomarker (G2783)

Target Name: GNB2

NCBI ID: G2783

GNB2

GNB2: A Drug Target and Potential Biomarker

Guanine nucleotide-binding proteins (GNB2) are a family of transmembrane proteins that play a crucial role in cellular signaling pathways. GNB2s are involved in various physiological processes, including DNA replication, cell growth, and apoptosis. The GNB2 gene has four splice variants, represented by the codes SSS4, NEDHYDF, ANK2, and FBN1. In this article, we will focus on GNB2 (SSS4; NEDHYDF), which is a drug target and a potential biomarker for various diseases.

Structure and Function

GNB2 is a 21-kDa protein that consists of an N-terminal transmembrane domain, a coiled-coil domain, and a C-terminal cytoplasmic domain. The N-terminal transmembrane domain is responsible for the protein's cytoplasmic localization and for interacting with various intracellular signaling molecules. The coiled-coil domain is responsible for the protein's stability and for playing a role in GNB2's intracellular signaling. The C-terminal cytoplasmic domain is responsible for the protein's interaction with DNA and for its role in DNA replication and repair.

GNB2 is involved in various cellular signaling pathways, including the regulation of DNA replication, cell growth, and apoptosis. In addition to its role in DNA replication, GNB2 is also involved in the regulation of cell growth and apoptosis. GNB2 has been shown to play a role in the regulation of cell cycle progression, cell growth, and cell death.

GNB2 has also been shown to be involved in the regulation of DNA repair. DNA repair is a crucial process that helps cells maintain genetic stability and repair any DNA damage that may be caused by mutations or other forms of stress. GNB2 has been shown to play a role in the regulation of DNA repair by facilitating the recruitment of DNA repair factors to damaged DNA.

Drug Targeting

GNB2 is a drug target of interest due to its involvement in various cellular signaling pathways. Several studies have shown that GNB2 can be targeted by small molecules, including inhibitors of the protein's catalytic activity and inhibitors of its interaction with intracellular signaling molecules. In addition to small molecules, Gnb2 can also be targeted by antibodies that specifically recognize the protein.

Biomarker Potential

GNB2 has also been shown to be a potential biomarker for various diseases. The GNB2 gene has been shown to be involved in the regulation of various cellular processes, including DNA replication, cell growth, and apoptosis. As a result, GNB2 has been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Conclusion

In conclusion, GNB2 (SSS4; NEDHYDF) is a drug target and a potential biomarker for various diseases. Its role in the regulation of DNA replication, cell growth, and apoptosis makes it an attractive target for small molecules and antibodies. As more research is done on GNB2, it is likely that new insights into its biology and its potential as a drug target and biomarker will emerge.

Protein Name: G Protein Subunit Beta 2

Functions: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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