GNAI1: A Heterotrimeric Guanine Nucleotide-Binding Protein 1B

Target Name: GNAI1

NCBI ID: G2770

GNAI1

GNAI1: A Heterotrimeric Guanine Nucleotide-Binding Protein 1B

Guanine nucleotide-binding proteins (GNBPs) are a family of transmembrane proteins that play a crucial role in various cellular processes, including DNA replication, repair, and signaling. GNAI1, a heterotrimeric GNBP, is a protein that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

GNAI1 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and pancreas. It is localized to the endoplasmic reticulum (ER) and has been shown to play a role in regulating cellular processes, including cell adhesion, migration , and survival. GNAI1 has also been shown to interact with various protein partners, including histone deacetylases (HDACs), which are enzymes that remove acetyl groups from histones, leading to changes in gene expression.

One of the most significant functions of GNAI1 is its role in the regulation of DNA replication. GNAI1 has been shown to interact with the protein complex known as the mitochondrial DNA replication complex, which includes the protein DnaC, 馃槈 DnaE, 鈥嬧?媋nd DnaF. DnaC is a key component of the complex and is responsible for the initiation of DNA replication, while DnaE and DnaF are responsible for the regulation of the replication process. GNAI1 has been shown to play a critical role in the regulation of DnaE and DnaF, by interacting with their protein partners and regulating their activity.

In addition to its role in DNA replication, GNAI1 has also been shown to be involved in the regulation of cell adhesion and migration. GNAI1 has been shown to interact with the protein known as E-cadherin, which is a transmembrane protein that plays a critical role in cell-cell adhesion. GNAI1 has also been shown to regulate the activity of the protein known as vimentin, which is involved in cell migration.

GNAI1 has also been shown to be involved in the regulation of various signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cellular processes, including cell survival, growth, and angiogenesis. GNAI1 has been shown to interact. with the protein known as p110, which is a key component of the PI3K/Akt signaling pathway.

GNAI1 has also been shown to be involved in the regulation of cellular processes related to neurodegenerative diseases. GNAI1 has been shown to interact with the protein known as Tau, which is a component of the neuroprotein tau. Tau is involved in the regulation of various cellular processes, including cell stability, axon growth, and neurotransmitter release. GNAI1 has also been shown to play a critical role in the regulation of Tau, by interacting with its protein partner and regulating its activity.

In addition to its role in neurodegenerative diseases, GNAI1 has also been shown to be involved in the regulation of various cardiovascular diseases. GNAI1 has been shown to interact with the protein known as Parp, which is involved in the regulation of DNA repair. Parp is also involved in the regulation of various cellular processes, including cell survival and angiogenesis. GNAI1 has also been shown to play

Protein Name: G Protein Subunit Alpha I1

Functions: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364)

The "GNAI1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GNAI1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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