GMPPA: A Potential Drug Target for Neurological Conditions (G29926)

Target Name: GMPPA

NCBI ID: G29926

GMPPA

GMPPA: A Potential Drug Target for Neurological Conditions

GMPPA, or GMPPA variant 2, is a protein that is expressed in the brain and has been shown to play a role in various neurological conditions, including Alzheimer's disease, Parkinson's disease, and depression. The molecule has also been shown to have potential as a drug target or biomarker, which could lead to new treatments for these debilitating conditions.

GMPPA is a transmembrane protein that is expressed in the brain and is involved in the regulation of various signaling pathways that are important for brain function. The protein is composed of four subunits that are held together by disulfide bonds. The two longest subunits contain a extracellular loop that is involved in the formation of the disulfide bonds.

GMPPA is involved in the regulation of several different signaling pathways that are important for brain function. One of the most well-studied signaling pathways that is regulated by GMPPA is the insulin/IGF-1 signaling pathway. This pathway is important for the regulation of energy metabolism and has been implicated in the development and progression of various neurological conditions, including Alzheimer's disease and Parkinson's disease.

GMPPA has also been shown to be involved in the regulation of the serotonin system, which is involved in the regulation of mood, appetite, and sleep. The serotonin system is known to be regulated by the neurotransmitter serotonin, which is synthesized from the amino acid tryptophan. GMPPA has been shown to play a role in the regulation of serotonin synthesis and uptake, which could have implications for the treatment of conditions that are characterized by disrupted serotonin signaling, such as depression.

In addition to its involvement in the insulin/IGF-1 and serotonin systems, GMPPA has also been shown to be involved in the regulation of other signaling pathways that are important for brain function. For example, the molecule has been shown to be involved in the regulation of the production of new neurons, which is important for the development and maintenance of neural circuitry. Additionally, GMPPA has been shown to play a role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time.

GMPPA has also been shown to be involved in the regulation of inflammation, which is a critical aspect of the development and progression of many neurological conditions. The molecule has been shown to play a role in the regulation of the production of pro-inflammatory cytokines, which are important for the recruitment of immune cells to the site of inflammation. This suggests that GMPPA may have implications for the treatment of conditions characterized by inflammation, such as multiple sclerosis and rheumatoid arthritis.

GMPPA has also been shown to be involved in the regulation of the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles and other aberrant aggregates. GMPPA has been shown to play a role in the regulation of the formation of these aberrant aggregates and may have implications for the treatment of these conditions.

In addition to its involvement in the regulation of brain function, GMPPA has also been shown to have potential as a drug target or biomarker. The molecule has been shown to interact with a variety of different compounds, including small molecules, peptides, and proteins. Many of these interactions have been shown to have implications for the regulation of brain function and the development of various neurological conditions. For example, GMPPA has been shown to interact with the protein huntingtin, which is known to be involved in the development of Alzheimer's disease. Additionally, GMPPA has been shown to interact with the protein parkin, which is known to

Protein Name: GDP-mannose Pyrophosphorylase A

Functions: May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose

The "GMPPA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GMPPA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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