TRBC1: A Protein Implicated in Cancer Treatment (G28639)

Target Name: TRBC1

NCBI ID: G28639

TRBC1

TRBC1: A Protein Implicated in Cancer Treatment

TRBC1 (Tumor-associated Regulatory Binding Cell 1) is a protein that is expressed in various tissues of the body, including the skin, lung, and gastrointestinal tract. It is a member of the TGF-β signaling pathway, which is a well-known pathway that regulates cell growth, differentiation, and survival. The TRBC1 protein has been shown to play a role in the regulation of cell proliferation and has been identified as a potential drug target in various diseases, including cancer.

The TRBC1 protein is composed of 1,262 amino acid residues and has a calculated molecular mass of 19.1 kDa. It is expressed in various tissues of the body, including the skin, lung, and gastrointestinal tract, and has been shown to be involved in the development and progression of various diseases.

One of the key functions of TRBC1 is its role in the regulation of cell proliferation. The TRBC1 protein has been shown to play a negative role in the growth and survival of cancer cells. In addition, TRBC1 has also been shown to play a role in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. This is important for the control of cell growth and the maintenance of tissue homeostasis.

Another function of TRBC1 is its role in the regulation of cell adhesion. TRBC1 is involved in the formation of tight junctions, which are a type of cell-cell adhesion structure that helps to maintain tissue structure and function.

In addition to its functions in cell proliferation and adhesion, TRBC1 has also been shown to play a role in the regulation of cell migration. This is important for the development and progression of various diseases, including cancer.

The TRBC1 protein is also involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed. This is important for the delivery of oxygen and nutrients to tissues and is also important for the removal of waste products.

In conclusion, TRBC1 is a protein that plays a critical role in the regulation of cell proliferation, apoptosis, adhesion, migration, and angiogenesis. As a result, TRBC1 has been identified as a potential drug target for the treatment of various diseases, including cancer. Further research is needed to fully understand the functions of TRBC1 and to develop effective treatments for these diseases.

Protein Name: T Cell Receptor Beta Constant 1

Functions: Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585)

The "TRBC1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRBC1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets