AKR1C8: A Potential Drug Target and Biomarker (G340811)

Target Name: AKR1C8

NCBI ID: G340811

AKR1C8

AKR1C8: A Potential Drug Target and Biomarker

AKR1C8, also known as Aldo-keto reductase family 1 member C8, is a gene that encodes a protein involved in the detoxification of aromatic amides, which are compounds that are commonly found in environmental and consumer products such as plastics, solvents, and textiles. The human body produces several enzymes that can break down these compounds, but some are still not fully understood. The function of AKR1C8 in the detoxification of these compounds is still being studied, but its potential as a drug target and biomarker is being investigated.

The AKR1C8 gene was first identified in 2006 and has been extensively studied since. It is a member of the Aldo-keto reductase family 1, which includes a variety of enzymes involved in the detoxification of aromatic amides. The human AKR1C8 gene is responsible for producing a protein that belongs to the C8 subfamily of this family. This protein is involved in the detoxification of several different aromatic amides, including o-xylenes, which are commonly found in environmental and consumer products such as plastics, solvents, and textiles.

The detoxification of aromatic amides by AKR1C8 is a complex process that involves several steps. The first step is the formation of an intermediate compound, which is then converted to the final product through several additional steps. The exact mechanism of the detoxification process is not fully understood, but it is known that the AKR1C8 enzyme plays a crucial role in breaking down these compounds.

As a drug target, AKR1C8 has the potential to be used for the treatment of several conditions associated with the detoxification of aromatic amides. For example, some studies have suggested that people with certain genetic variations in the AKR1C8 gene may be at increased risk for developing certain diseases, such as cancer. By targeting these genetic variations, researchers may be able to develop new treatments for these conditions. Additionally, the AKR1C8 enzyme has also been shown to be involved in the production of several harmful compounds, such as polycyclic aromatic hydrocarbons (PAHs) and polycyclic aromatic nitrogen compounds (PANs), which are known to be cancer-causing agents. By targeting AKR1C8, researchers may be able to develop new treatments for certain types of cancer.

In addition to its potential as a drug target, AKR1C8 has also been shown to be a potential biomarker for several different conditions. For example, some studies have suggested that the levels of AKR1C8 in the body may be affected by exposure to certain chemicals, such as those found in textiles and consumer products. By measuring the levels of AKR1C8 in these substances, researchers may be able to monitor exposure and identify potential health risks. Additionally, the AKR1C8 enzyme has also been shown to be involved in the production of several different compounds, including aromatic amides, which may be useful as biomarkers for certain types of cancer.

Overall, the study of AKR1C8 is still in its early stages, and much more research is needed to fully understand its function in the detoxification of aromatic amides and its potential as a drug target and biomarker. Further studies are needed to determine the exact mechanism of the AKR1C8 enzyme and its role in the detoxification of these compounds. Additionally, further research is needed to investigate the potential clinical applications of AKR1C8 as a drug target and biomarker.

Protein Name: Aldo-keto Reductase Family 1 Member C8

The "AKR1C8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AKR1C8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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