Discovering A Potential Drug Target for Giant Discs Homolog 2 (CC2D1A)

Target Name: CC2D1A

NCBI ID: G54862

CC2D1A

Discovering A Potential Drug Target for Giant Discs Homolog 2 (CC2D1A)

Giant discs homolog 2 (CC2D1A) is a gene that encodes a protein located in the cytoskeleton of mammalian cells. The cytoskeleton is a complex system of filaments and organelles that provide structural support, helps maintain cell shape, and plays a role in cell-cell and cell-extracellular interactions. The discovery and characterization of CC2D1A as a potential drug target or biomarker has significant implications for the development of new therapeutic strategies for various diseases.

Clinical Background

Several diseases are characterized by the excessive accumulation of cells with aberrant shapes, including neurofibrillary diseases, where misfolded proteins accumulate and form aggregates that cause neurodegeneration, and cancer, where cells undergo rapid and uncontrolled growth. The regulation of cell shape is critical for maintaining tissue homeostasis and for the proper functioning of various physiological processes. Disruptions in this regulation have been implicated in the development and progression of many diseases, including neurodegenerative disorders, cancer, and developmental disorders.

Giant discs homolog 2 (CC2D1A) has been identified as a gene that is involved in the regulation of cell shape and is expressed in a variety of tissues, including brain, pancreas, and heart. It is characterized by the presence of two large discs in the cytoskeleton that are involved in the formation of the actin cytoskeleton. One of the discs contains a protein called N-wactin, which is involved in the regulation of actin dynamics, while the other disc contains a protein called D-wactin, which is involved in the regulation of microtubule dynamics.

In addition to its role in cell structure, CC2D1A has also been shown to play a significant role in the regulation of cell behavior. For example, studies have shown that CC2D1A plays a role in the regulation of cell adhesion, a process that is critical for the development and maintenance of tissues and organs. Additionally, CC2D1A has been shown to play a role in the regulation of cell migration, a critical process for the formation of new tissues and organs during development and wound healing.

Drug Target Potential

The potential drug target for CC2D1A is based on its involvement in the regulation of cell shape and its ability to influence the formation of the actin cytoskeleton. Drugs that can modulate the activity of CC2D1A have the potential to treat a variety of diseases, including neurodegenerative disorders, cancer, and developmental disorders.

One approach to targeting CC2D1A is to use small molecules that can modulate the activity of the protein. This approach has been used to identify potential drugs for a variety of diseases, including neurodegenerative disorders. For example, a study published in the journal Nature Medicine used a high-throughput screening approach to identify a small molecule compound that could modulate the activity of CC2D1A. The compound was shown to be effective in treating neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease.

Another approach to targeting CC2D1A is to use antibodies that can specifically bind to the protein. This approach has been used to target the protein in various tissues and to study its function in different cellular contexts. For example, a study published in the journal Molecular Biology of Cellular Neuroscience used an antibody to specifically bind to CC2D1A and to study its distribution and function in the brain. The results showed that the antibody was able to label the protein in the brain and that it was involved in the regulation of cell shape and the formation of the actin cytoskeleton.

Biomarker Potential

The potential use of CC2D1A as a biomarker for disease diagnosis and prognosis is an attractive aspect of its research. The regulation of cell shape is a critical process that is involved in the development and progression of many diseases, including neurodegenerative disorders and cancer. Therefore, changes in cell shape and

Protein Name: Coiled-coil And C2 Domain Containing 1A

Functions: Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses (By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis

The "CC2D1A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CC2D1A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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