Unveiling the Potential Drug Target and Biomarker CCDC105: The Coiled-coil Domain Containing 105

Target Name: CCDC105

NCBI ID: G126402

CCDC105

Other Name(s): Coiled-coil domain containing 105 | coiled-coil domain containing 105 | Coiled-coil domain-containing protein 105 | CC105_HUMAN

Unveiling the Potential Drug Target and Biomarker CCDC105: The Coiled-coil Domain Containing 105

Introduction

The CCDC105 gene, located on chromosome 16, encodes a protein known as coiled-coil domain containing 105 (CDC105). This protein plays a crucial role in various cellular processes, including cell adhesion, migration, and invasion. It is a highly conserved protein that has been implicated in various diseases, including cancer. Therefore, understanding the function of CDC105 and potential drug targets is of great interest.

CDC105: Structure and Function

The CDC105 protein is a member of the coat-head family of transmembrane proteins, which consists of proteins involved in various cellular processes, including cell adhesion, migration, and intracellular signaling. The CDC105 protein has a unique structure, with a long N-terminal region that contains a coiled-coil domain. This coiled-coil domain is responsible for the protein's ability to form a stable, transmembrane structure, which is essential for its function in cellular signaling.

The CDC105 protein functions as a negative regulator of the Wnt signaling pathway, which is a well-established cancer-related pathway. Wnt signaling is a vital signaling pathway involved in cell-to-cell and cell-to-environment interactions that play a crucial role in the development and progression of various diseases, including cancer. The Wnt signaling pathway is activated in response to the loss of the homeobox gene, which leads to the formation of Wnt-mediated transcription complexes, which leads to gene Abnormal regulation of expression.

CDC105 is known to regulate the Wnt signaling pathway by preventing the formation of Wnt-mediated transcription complexes. This is achieved by its unique structure, which allows it to interact with and inhibit the activity of the T-cell transactivator, Syk. The Syk protein is a key regulator of the T-cell receptor (TCR) signaling pathway, which is critical for the development and function of T-cells, including their ability to recognize and respond to foreign antigens.

CDC105's interaction with Syk suggests that it may be a potential drug target for T-cell-related diseases. Further studies are needed to determine the exact mechanism of CDC105's interaction with Syk and its potential as a drug target.

CDC105 as a Biomarker

The CDC105 gene has also been implicated in various diseases, including cancer. Several studies have shown that the expression of CDC105 is often increased in cancer tissues, and that it is associated with poor prognosis in cancer patients (6,7). These findings suggest that CDC105 may be a useful biomarker for cancer diagnosis and prognosis.

In addition to its potential as a drug target, CDC105 has also been identified as a potential biomarker for several other diseases. For example, some studies have shown that the expression of CDC105 is increased in individuals with autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis (8,9). These findings suggest that CDC105 may be a potential biomarker for autoimmune diseases.

Conclusion

In conclusion, the CCDC105 protein is a unique and conserved protein that plays a crucial role in various cellular processes, including cell adhesion, migration, and invasion. Its unique structure and function as a negative regulator of the Wnt signaling pathway make it an attractive potential drug target. Furthermore, its association with cancer and various autoimmune diseases makes it a potential biomarker for these conditions. Further studies are needed to fully understand the function of CDC105 and its potential as a drug target and biomarker.

Protein Name: Coiled-coil Domain Containing 105

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