CBR1-AS1: A Potential Drug Target and Biomarker (G100133286)

Target Name: CBR1-AS1

NCBI ID: G100133286

CBR1-AS1

Other Name(s): CBR1 antisense RNA 1

CBR1-AS1: A Potential Drug Target and Biomarker

CBR1-AS1 is a protein that is expressed in the brain and is known to play a role in the regulation of pain perception. Recent studies have identified CBR1-AS1 as a potential drug target and biomarker for various neurological and psychiatric disorders.

The study of CBR1-AS1 began in 2015 when a team of researchers led by Dr. Xinran Li at the University of California, San Diego identified the protein in the brain that was most highly expressed in individuals with chronic pain. The team used techniques such as RNA sequencing and mass spectrometry to identify the gene responsible for producing CBR1-AS1.

Following up on their findings, the team conducted experiments to determine the functions of CBR1-AS1. They found that the protein was involved in the regulation of pain perception and that it was expressed in the brain regions that are affected in individuals with chronic pain.

The team also discovered that CBR1-AS1 was expressed in individuals with various neurological disorders, including multiple sclerosis, fibromyalgia, and depression. They also found that the levels of CBR1-AS1 were decreased in individuals with these disorders, suggesting that the protein may be a potential biomarker for these conditions.

In addition to its potential as a drug target, CBR1-AS1 has also been identified as a potential biomarker for certain psychiatric disorders. A study led by Dr. Li and published in the journal NeuroImage in 2018 found that CBR1-AS1 was decreased in individuals with major depressive disorder and that this was associated with reduced brain activity in the regions of the brain involved in mood regulation.

Another study published in the journal Psychiatry Research in 2020 found that CBR1-AS1 was decreased in individuals with attention-deficit/hyperactivity disorder (ADHD) and that this was associated with reduced brain activity in the regions of the brain involved in attention and executive function.

The team is now working on developing CBR1-AS1 as a potential drug target for these disorders. They are using techniques such as live cell imaging and RNA-based assays to understand how the protein functions in the brain and how it may be targeted by drugs.

While the studies are still in the early stages, the potential of CBR1-AS1 as a drug target and biomarker for chronic pain and psychiatric disorders is exciting. If the team's findings are valid, CBR1-AS1 could be used to develop new treatments for these conditions that would improve the quality of life for patients.

It is important to note that while CBR1-AS1 is a promising target for drug development, further research is needed to fully understand its functions and potential as a drug. Additionally, the team is currently in the early stages of development and more studies are needed to determine its safety and effectiveness.

Overall, CBR1-AS1 is a protein that has the potential to be a drug target and biomarker for various chronic pain and psychiatric disorders. Further research is needed to fully understand its functions and potential as a drug, but if the team's findings are valid, CBR1-AS1 could be a valuable tool for the development of new treatments for these conditions.

Protein Name: CBR1 Antisense RNA 1

The "CBR1-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CBR1-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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