FLJ55807: A NOTCH2 Gene Variant in The Regulation of Stem Cell Proliferation and Differentiation

Target Name: NOTCH2NLA

NCBI ID: G388677

NOTCH2NLA

FLJ55807: A NOTCH2 Gene Variant in The Regulation of Stem Cell Proliferation and Differentiation

NOTCH2NLA (FLJ55807) is a protein that is expressed in various tissues of the body, including the nervous system, endothelial cells, and epithelial cells. Its name comes from Notch signaling pathway, which is a well-known cellular communication pathway that regulates stem cells proliferation, tissue repair, and regeneration.

The NOTCH signaling pathway is a transgenic approach to studying gene function, where the NOTCH1 gene is introduced into a cell to analyze the effects of NOTCH signaling on the cell. The NOTCH2 gene is then introduced as a control, to ensure that any effects observed in the NOTCH1-expressed cells are not due to the introduction of the NOTCH1 gene.

FLJ55807 is a variant of the NOTCH2 gene that has been shown to play a unique role in the NOTCH signaling pathway. It is expressed in the endothelial cells, which are responsible for forming the lining of various body tissues and lumen, and it has been shown to be involved in the regulation of cell proliferation, migration, and angiogenesis.

FLJ55807 has also been shown to be involved in the regulation of the Notch2 signaling pathway. The Notch2 gene is a NOTCH1 gene that is expressed in various tissues, including the nervous system, and is involved in the regulation of stem cell proliferation and differentiation. NOTCH2 gene has four exons, which result in a protein that has a unique structure and function compared to the NOTCH1 gene.

FLJ55807 has been shown to interact with the NOTCH2 gene in a variety of ways. Firstly, it has been shown to physically interact with the NOTCH2 gene, which results in the formation of a complex between the two proteins. This complex is thought to play a role in the regulation of NOTCH2 signaling pathway.

Secondly, FLJ55807 has been shown to regulate the NOTCH2 gene through the inhibition of its translation. This process is called "Post-Translational Modification" (PTM), which is a way of modifying the function of a protein after its synthesis, but before it is translated into a functional protein. FLJ55807 has been shown to use a specific PTM mechanism to regulate the NOTCH2 gene, which results in the translation of the NOTCH2 gene being reduced.

Thirdly, FLJ55807 has been shown to regulate the NOTCH2 gene through the modulation of its stability. This process is called \"Protein stability\" and it is a way of regulating the amount of a protein that is available for interaction with other proteins. FLJ55807 has been shown to use a specific mechanism to regulate the stability of the NOTCH2 gene, which results in the stability of the NOTCH2 protein being increased.

In conclusion, FLJ55807 is a protein that has been shown to play a unique role in the NOTCH signaling pathway. Its interaction with the NOTCH2 gene, regulation of NOTCH2 translation and stability, and role in the regulation of stem cell proliferation and differentiation make FLJ55807 an attractive drug target and a potential biomarker for various diseases. Further research is needed to fully understand the role of FLJ55807 in the NOTCH signaling pathway and its potential as a drug.

Protein Name: Notch 2 N-terminal Like A

Functions: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29856954, PubMed:29856955, PubMed:29561261). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity)

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