KRT8P37: A Potential Drug Target and Biomarker (G100287325)
KRT8P37: A Potential Drug Target and Biomarker
Kallikrein-related peptidases (KRTs) are a family of enzymes that belong to the serine proteases superfamily 11 (SP11) and are involved in various physiological processes in the body, including tissue repair, inflammation, and immune responses. KRT8P37 is a specific KRT enzyme that is of interest due to its potential as a drug target and biomarker.
The KRT8P37 enzyme is a 14-kDa protein that is expressed in various tissues and organs, including the liver, spleen, heart, kidneys, and pancreas. It is highly conserved, with a calculated pI of 6.9 and a predicted localization in the cytoplasm. KRT8P37 is also known to be a potent serine protease, capable of catalyzing the hydrolysis of a wide range of peptides with different lengths and sizes.
KRT8P37 has been shown to play a critical role in various physiological processes, including inflammation, tissue repair, and cell signaling. For example, KRT8P37 has been shown to participate in the immune response by regulating the production of pro-inflammatory cytokines. In addition, KRT8P37 has been shown to play a role in tissue repair and regeneration following injury or disease, by regulating the production of extracellular matrix (ECM) components and promoting the clearance of damaged cells.
Due to its potential role in various physiological processes, KRT8P37 has been identified as a potential drug target. Several studies have shown that KRT8P37 can be inhibited by small molecules, including inhibitors of serine proteases and other enzymes that are involved in the regulation of KRT8P37 activity. Additionally, several studies have shown that inhibition of KRT8P37 can lead to the inhibition of various cellular processes, including cell signaling, cell migration, and the production of pro-inflammatory cytokines.
In addition to its potential as a drug target, KRT8P37 has also been shown to be a potential biomarker for various diseases. For example, KRT8P37 has been shown to be downregulated in various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Additionally, KRT8P37 has been shown to be involved in the development and progression of certain diseases, such as uveal cancer and melanoma.
Overall, KRT8P37 is a promising drug target and biomarker due to its potential role in various physiological processes and its involvement in the development and progression of various diseases. Further research is needed to fully understand the role of KRT8P37 in these processes and to develop effective inhibitors or diagnostic tools for this protein.
Protein Name: Keratin 8 Pseudogene 37
More Common Targets
KRT8P39 | KRT8P44 | KRT8P46 | KRT8P48 | KRTAP16-1 | KRTAP20-4 | KRTAP21-3 | KRTAP22-2 | KRTAP25-1 | KRTAP29-1 | KRTAP4-7 | KRTAP4-9 | KRTAP9-6 | KRTAP9-7 | KTN1-AS1 | L1CAM-AS1 | L1TD1 | LAMTOR3P1 | LAMTOR5-AS1 | LARGE-AS1 | LARGE2 | LCA5 | LCDR | LCE4A | LCIIAR | LCT-AS1 | LCTL | LDHBP1 | LDHD | LEFTY2 | LEPROT | LEXM | LGALS8-AS1 | LGI4 | LHFPL2 | LHFPL6 | LHX4-AS1 | LIFR-AS1 | LIMS3-LOC440895 | LIMS4 | LIN28B-AS1 | LINC-ROR | LINC00029 | LINC00092 | LINC00102 | LINC00111 | LINC00112 | LINC00113 | LINC00158 | LINC00159 | LINC00160 | LINC00161 | LINC00173 | LINC00184 | LINC00189 | LINC00210 | LINC00240 | LINC00276 | LINC00278 | LINC00308 | LINC00311 | LINC00331 | LINC00333 | LINC00348 | LINC00351 | LINC00353 | LINC00358 | LINC00364 | LINC00398 | LINC00400 | LINC00402 | LINC00421 | LINC00423 | LINC00424 | LINC00426 | LINC00440 | LINC00446 | LINC00457 | LINC00462 | LINC00466 | LINC00484 | LINC00499 | LINC00501 | LINC00506 | LINC00507 | LINC00513 | LINC00534 | LINC00536 | LINC00538 | LINC00539 | LINC00540 | LINC00557 | LINC00559 | LINC00562 | LINC00563 | LINC00564 | LINC00566 | LINC00570 | LINC00571 | LINC00578