KRTAP1-5: A Potential Drug Target and Biomarker (G83895)

Target Name: KRTAP1-5

NCBI ID: G83895

KRTAP1-5

KRTAP1-5: A Potential Drug Target and Biomarker

Keratin-associated protein 1.5 (KRTAP1-5) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and subcellular localization make it an attractive target for small molecules and antibodies. In this article, we will discuss the biology of KRTAP1-5, its potential drug targets, and its potential as a biomarker for various diseases.

Structure and Localization

KRTAP1-5 is a 19 kDa protein that is expressed in most tissues and cells of the body. It is highly conserved and has a similar structure in all its splice variants. KRTAP1-5 has a unique molecular architecture, with a four-pass transmembrane region that is rich in conserved amino acid sequences. It has a single extracellular domain, which consists of a N-terminal alpha-helix, a middle transmembrane region, and a C-terminal T-loop.

KRTAP1-5 is highly localized to the cytoplasm and has a subcellular localization in the endoplasmic reticulum (ER) and the transendoplasmic reticulum (TPR). It is predominantly nuclear in localization, with a minor cytoplasmic localization. Its nuclear localization is dependent on the presence of K+ ions, which are released from the endoplasmic reticulum and bind to the protein.

Function and Potential Drug Targets

KRTAP1-5 is involved in various cellular processes, including cell signaling, cytoskeletal organization, and stress response. It plays a role in the regulation of cell adhesion, cell-cell interactions, and intracellular signaling pathways. It is also involved in the regulation of cell cycle progression, and has been shown to play a role in the regulation of microtubule dynamics.

KRTAP1-5 has been identified as a potential drug target due to its unique structure and subcellular localization. Its conserved amino acid sequences and subcellular localization make it a promising target for small molecules and antibodies. Additionally, its involvement in various cellular processes makes it an attractive target for drugs that can modulate its activity and improve cellular signaling pathways.

Potential Biomarkers

KRTAP1-5 has been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and subcellular localization make it an attractive target for diagnostic agents that can detect and quantify its expression in various tissues and cells.

In cancer, KRTAP1-5 has been shown to be involved in various cellular processes that are associated with cancer progression. Its expression has been shown to be increased in various types of cancer, including breast cancer, lung cancer, and colorectal cancer. Additionally, Its expression has been shown to be associated with cancer cell survival and invasiveness.

In neurodegenerative diseases, KRTAP1-5 has been shown to be involved in the regulation of cellular processes that are associated with neurodegeneration. Its expression has been shown to be increased in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Additionally , its expression has been shown to be associated with neurodegenerate behavior and cognitive impairment.

In autoimmune disorders, KRTAP1-5 has been shown to be involved in the regulation of cellular processes that are associated with autoimmune disease. Its expression has been shown to be increased in various autoimmune disorders, including rheumatoid arthritis, multiple sclerosis, and guillain-barre syndrome. Additionally, its expression has been shown to be associated with autoimmune disease-related proteins and autoantibodies.

Conclusion

In conclusion, KRTAP1-5 is a unique protein that has

Protein Name: Keratin Associated Protein 1-5

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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