KRTAP10-1: A Potential Drug Target and Biomarker (G386677)

Target Name: KRTAP10-1

NCBI ID: G386677

KRTAP10-1

KRTAP10-1: A Potential Drug Target and Biomarker

KRTAP10-1 (KAP10.1), a gene encoding a protein involved in the K-type voltage-dependent anion channels, has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. The K-type voltage-dependent anion channels are a family of transmembrane proteins that play a crucial role in the regulation of ion channels and are involved in the production of various signaling molecules that contribute to neuronal excitability and synaptic communication. The dysfunction of these channels has been implicated in a wide range of neurological and psychiatric disorders, including epilepsy, schizophrenia, and mood disorders.

KRTAP10-1 is a member of the K-type voltage-dependent anion channels gene family, which includes several related genes, including KRTAP10-2, KRTAP10-3, and KRTAP10-4. These genes are located on chromosome 6p21 and encode proteins that share a conserved catalytic core and a variable region that includes transmembrane regions and intracellular loops. KRTAP10-1 is characterized by a single open reading frame (ORF) that spans 1,974 base pairs and contains a unique N-terminus that is distinct from the other K-type voltage-dependent anion channels.

The function of KRTAP10-1 is not well understood, but its expression has been shown to be involved in a variety of physiological processes, including neuronal excitability and synaptic communication. KRTAP10-1 has been shown to play a role in the regulation of ion channels, including the K-type voltage-dependent anion channels, which are involved in the production of various signaling molecules that contribute to neuronal excitability and synaptic communication.

In addition to its role in ion channels, KRTAP10-1 has also been shown to be involved in the regulation of cell signaling pathways that are involved in neuronal development, differentiation, and survival. For example, studies have shown that KRTAP10-1 is involved in the regulation of the Wnt signaling pathway, a well-established pathway that is involved in the regulation of cell growth, differentiation, and survival. Additionally, KRTAP10-1 has also been shown to be involved in the regulation of the Notch signaling pathway, a signaling pathway that is involved in the regulation of cell survival and differentiation.

The potential drug target status of KRTAP10-1 is supported by its expression in several neuropsychiatric disorders, including epilepsy, schizophrenia, and mood disorders. Studies have shown that individuals with certain genetic variations in the KRTAP10-1 gene are at increased risk for the development of these disorders. For example, studies have shown that individuals with a specific genetic variation, known as rs1012205, are at increased risk for the development of epilepsy and schizophrenia. Additionally, individuals with certain genetic variations in the KRTAP10-1 gene have also been shown to have increased symptoms of mood disorders.

The potential biomarker status of KRTAP10-1 is also supported by its expression in several neuropsychiatric disorders, including epilepsy, schizophrenia, and mood disorders. Studies have shown that individuals with certain genetic variations in the KRTAP10-1 gene are at increased risk for the development of these disorders. For example, studies have shown that individuals with a specific genetic variation, known as rs1012205, are at increased risk for the development of epilepsy and schizophrenia. Additionally, individuals with certain genetic variations in the KRTAP10-1 gene have also been shown to have increased symptoms of mood disorders.

In conclusion, KRTAP10-1 is a gene that encodes a protein involved in the K-type voltage-dependent anion channels and has been identified as a potential drug target and biomarker for several neurological and psychiatric disorders. The dysfunction of these channels has been implicated in a wide range of disorders, including epilepsy, schizophrenia, and mood disorders, and the potential drug targets and biomarkers associated with

Protein Name: Keratin Associated Protein 10-1

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP10-1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP10-1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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