KRTAP1-3: A Protein Implicated in Pain Perception and Neurodegenerative Diseases

Target Name: KRTAP1-3

NCBI ID: G81850

KRTAP1-3

KRTAP1-3: A Protein Implicated in Pain Perception and Neurodegenerative Diseases

KRTAP1-3 (KRA13_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, liver, and pancreas. It is a member of the Kallikrein-related peptidases (KAPs) family, which includes a variety of serine proteases that regulate proteolytic enzymes and contribute to tissue injury and repair.

KRTAP1-3 is involved in the regulation of a variety of cellular processes, including cell signaling, inflammation, and fibrosis. Its function as a drug target or biomarker is under investigation in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of KRTAP1-3 is its role in the regulation of pain perception. KRTAP1-3 has been shown to play a key role in the production of pain-related neurochemicals, such as calcitonin, which is a hormone that regulates pain sensitivity. In addition, KRTAP1-3 has been shown to interact with other pain-related molecules, including nociceptins, which are involved in pain perception.

In neurodegenerative diseases, such as Alzheimer's disease, KRTAP1-3 has been shown to be involved in the development and progression of neurodegeneration. Studies have shown that KRTAP1-3 levels are decreased in the brains of individuals with Alzheimer's disease, and that inhibition of KRTAP1-3 has been shown to protect against neurodegeneration in these individuals.

In addition to its role in pain perception and neurodegenerative diseases, KRTAP1-3 is also being investigated as a potential drug target for various oncology types. For example, KRTAP1-3 has been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels grow in response to cancer growth. In addition, KRTAP1-3 has been shown to interact with the transcription factor, NF-kappa-B, which is involved in cancer cell growth and survival.

Overall, KRTAP1-3 is a protein that is involved in a variety of cellular processes that are important for human health and disease. As a drug target or biomarker, KRTAP1-3 is under investigation in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand its role in these diseases and to develop effective treatments.

Protein Name: Keratin Associated Protein 1-3

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP1-3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP1-3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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