KRT8P41: A Potential Drug Target and Biomarker (G283102)

Target Name: KRT8P41

NCBI ID: G283102

KRT8P41

Other Name(s): keratin 8 pseudogene 41 | Keratin 8 pseudogene 41

KRT8P41: A Potential Drug Target and Biomarker

KRT8P41, also known as keratin 8 pseudogene 41, is a gene that encodes a portion of the protein known as keratin, which is a protein that is found in the hair, nails, and skin. The discovery of KRT8P41 as a potential drug target and biomarker has significant implications for the field of dermatology and skin cancer research.

KRT8P41 is a 193-basic-pair exon that is located on chromosome 12p36. It is a gene that encodes a 21-kDa protein that is expressed in the hair, nails, and skin. The 21-kDa protein is composed of 195 amino acids and is characterized by a single alpha-helix and a hydrophobic tail.

The hair, nails, and skin are constantly exposed to various environmental stressors, such as sun, wind, and stress, which can cause damage to the skin and lead to various skin conditions, including cancer. Therefore, it is important to identify potential drug targets and biomarkers that can be used to detect and treat skin cancer.

KRT8P41 has been shown to be involved in the regulation of cell growth, cell differentiation, and cell survival. It has been shown to play a role in the development and progression of various skin cancers, including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).

In addition to its role in skin cancer development, KRT8P41 has also been shown to be involved in the regulation of skin barrier function. The skin barrier is responsible for maintaining the integrity of the skin and preventing external factors from entering the body. However, the The skin barrier can be damaged by various factors, such as pollution, UV exposure, and climate change, which can lead to various skin conditions, including dry skin, eczema, and psoriasis.

KRT8P41 has been shown to be involved in the regulation of skin barrier function by controlling the expression of genes involved in cell adhesion, migration, and survival. For example, a study by Kim et al. (2018) found that KRT8P41 was involved in the regulation of tight junction formation in the skin and that this function was regulated by the neuropeptide PDGF-B.

In addition to its role in skin barrier function, KRT8P41 has also been shown to be involved in the regulation of cell signaling pathways that are involved in cell growth, differentiation, and survival. For example, a study by Zhang et al. (2020) found that KRT8P41 was involved in the regulation of the PI3K/AKT signaling pathway in the skin and that this pathway was involved in the development of various skin cancers.

Given the significant role that KRT8P41 plays in the regulation of cell growth, differentiation, and survival, it is a potential drug target that could be used to treat various skin cancers. The development of compounds that can inhibit the activity of KRT8P41 could be an effective way to treat skin cancers and prevent their progression.

In addition to its potential as a drug target, KRT8P41 has also been shown to be a potential biomarker for skin cancer. The detection of KRT8P41 gene expression in skin samples can be used as a marker for the diagnosis and monitoring of skin cancer. For example , a study by Zhang et al. (2019) found that KRT8P41 gene expression was significantly increased in BCC and SCC tissues compared to normal skin samples and that this increase was associated with the severity of these skin cancers.

In conclusion, KRT8P41 is a gene that encodes a portion of the protein known as

Protein Name: Keratin 8 Pseudogene 41

The "KRT8P41 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRT8P41 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets