MTHFD1: A Promising Drug Target for Neuroscience (G4522)

Target Name: MTHFD1

NCBI ID: G4522

MTHFD1

Other Name(s): MTHFD1 variant 1 | MTHFD | C-1-tetrahydrofolate synthase, cytoplasmic | epididymis secretory sperm binding protein | Epididymis secretory sperm binding protein | 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase | C-1-tetrahydrofolate synthase, cytoplasmic isoform 1 | C1-THF synthase | NADP-dependent cyclohydrolase/formyltetrahydrofolate synthetase | CIMAH | Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1, transcript variant 1 | Cytoplasmic C-1-tetrahydrofolate synthase | Methylenetetrahydrofolate dehydrogenase | C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed | 5,10-Methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase | C1TC_HUMAN | Formyltetrahydrofolate synthetase | Methenyltetrahydrofolate cyclohydrolase | cytoplasmic C-1-tetrahydrofolate synthase | methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 | MTHFC | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

MTHFD1: A Promising Drug Target for Neuroscience

MTHFD1, short for mid-brain-derived neurotrophic factor (BDNF), is a protein that is expressed in the midbrain, and is known for its role in the development and maintenance of neural circuitry. It is a potent regulator of neuronal survival and proliferation, and is involved in the formation of functional neural networks in the brain.

MTHFD1 is a single gene, and its encoded protein is a 21-kDa protein that is expressed in a variety of tissues throughout the body, including the brain. It is primarily expressed in the midbrain, and is also found in the hypothalamus, pituitary gland, and peripheral tissues. MTHFD1 is a member of the TGF-β family, and is characterized by a number of unique features that make it an attractive target for drug development.

One of the key characteristics of MTHFD1 is its ability to induce the expression of target genes. This is accomplished through the interaction of MTHFD1 with its downstream target, p53, which is a well-known transcription factor that plays a central role in the regulation of gene expression. MTHFD1 is able to induce the expression of p53 in a variety of cell types, and has been shown to play a role in the regulation of a wide range of cellular processes, including cell survival, proliferation, and differentiation.

Another important property of MTHFD1 is its ability to interact with other proteins. It is a potent inhibitor of the protein kinase A尾, and has been shown to play a role in the regulation of cellular processes that are influenced by A尾. MTHFD1 is also known to interact with the protein PDGF, and has been shown to play a role in the regulation of PDGF-dependent processes.

MTHFD1 is also characterized by a number of unique genetic variations that have been identified. These variations include single nucleotide variants (SNVs), insertions, and deletions (indels). Some of these variations have been shown to have a significant impact on the function of MTHFD1, and to contribute to its unique properties. For example, one variation has been shown to alter the stability of MTHFD1, leading to the formation of a conformational changes that alter its ability to interact with its downstream target, p53.

Despite these unique properties, MTHFD1 is still an attractive target for drug development due to its involvement in a wide range of cellular processes that are important for human health. It is involved in the regulation of cell survival and proliferation, and is implicated in a variety of neurological and psychiatric disorders. In addition, MTHFD1 is a potent inhibitor of A尾, and has been shown to have a potential therapeutic impact on Alzheimer's disease.

In conclusion, MTHFD1 is a highly promising drug target due to its unique properties and its involvement in a wide range of cellular processes that are important for human health. Further research is needed to fully understand the full potential of MTHFD1 as a therapeutic target, and to develop safe and effective drugs that can be used to treat a variety of neuropsychiatric disorders.

Protein Name: Methylenetetrahydrofolate Dehydrogenase, Cyclohydrolase And Formyltetrahydrofolate Synthetase 1

Functions: Trifunctional enzyme that catalyzes the interconversion of three forms of one-carbon-substituted tetrahydrofolate: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate, 5,10-methenyltetrahydrofolate and (6S)-10-formyltetrahydrofolate (PubMed:1881876, PubMed:10828945, PubMed:18767138). These derivatives of tetrahydrofolate are differentially required in nucleotide and amino acid biosynthesis, (6S)-10-formyltetrahydrofolate being required for purine biosynthesis while (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate is used for serine and methionine biosynthesis for instance (PubMed:25633902, PubMed:18767138)

The "MTHFD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MTHFD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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