Regulation of MTTHFD1L Activity By Acetyl-CoA and Phosphate (G25902)

Target Name: MTHFD1L

NCBI ID: G25902

MTHFD1L

Other Name(s): Mitochondrial C1-tetrahydrofolate synthase | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (isoform 2) | 10-formyl-THF synthetase | formyltetrahydrofolate synthetase domain containing 1 | Monofunctional C1-tetrahydrofolate synthase, mitochondrial | FTHFSDC1 | dJ292B18.2 | Monofunctional C1-tetrahydrofolate synthase, mitochondrial (isoform 1) | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like, transcript variant 1 | MTHFD1L variant 2 | C1TM_HUMAN | Formyltetrahydrofolate synthetase | MTC1THFS | Mitochondrial C1-tetrahydrofolate synthetase | MTHFD1L variant 1 | FLJ21145 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like | Formyltetrahydrofolate synthetase domain containing 1 | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like, transcript variant 2

Regulation of MTTHFD1L Activity By Acetyl-CoA and Phosphate

Mitochondrial C1-tetrahydrofolate synthase (MTTHFD1L) is a protein that plays a crucial role in the metabolism of folate, a B vitamin that is essential for the growth, development, and maintenance of the human body. MTHFD1L is a key enzyme in the citric acid cycle, also known as the Krebs cycle or TCA cycle, which is a central metabolic pathway that generates energy in the form of ATP from the food we eat.

MTHFD1L is a protein that is expressed in most tissues of the body and is involved in the synthesis of tetrahydrofolate, which is a key precursor of DNA, RNA, and proteins. MTHFD1L is also involved in the metabolism of other molecules, including pyrimidine, which is a precursor of DNA and RNA.

One of the unique features of MTHFD1L is its role in the regulation of folate metabolism. MTHFD1L is highly sensitive to changes in the levels of its substrate, acetyl-CoA, which is a key precursor for the citric acid cycle. MTHFD1L responds to changes in acetyl-CoA levels by regulating the rate at which it binds to the enzyme prosthetic group F1 and by affecting the rate at which it is activated by the prosthetic group H.

MTHFD1L is also involved in the regulation of the levels of its own activity. MTHFD1L has been shown to be regulated by several different factors, including its own levels of acetyl-CoA and its own levels of phosphate. MTHFD1L has been shown to be sensitive to changes in these levels and to regulate its own activity in response to changes in these levels.

MTHFD1L is a protein that is expressed in most tissues of the body and is involved in the synthesis of tetrahydrofolate and the regulation of folate metabolism. It is also involved in the regulation of its own activity and has been shown to be sensitive to changes in its levels of acetyl-CoA and phosphate. As a result, MTHFD1L is a potential drug target and could be used as a biomarker for a variety of diseases.

Protein Name: Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1 Like

Functions: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism complementing thus the enzymatic activities of MTHFD2

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