MTHFD2: A Potential Drug Target for The Synthesis of DNA and RNA

Target Name: MTHFD2

NCBI ID: G10797

MTHFD2

Other Name(s): NAD-dependent methylenetetrahydrofolate dehydrogenase | MTHFD2 variant 1 | Methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase, transcript variant 1 | Methenyltetrahydrofolate cyclohydrolase | MTDC_HUMAN | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | Methylene tetrahydrofolate dehydrogenase 2 | NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor | NMDMC

MTHFD2: A Potential Drug Target for The Synthesis of DNA and RNA

MTHFD2 (NAD-dependent methylenetetrahydrofolate dehydrogenase) is a enzyme involved in the metabolism of methylenetetrahydrofolate (MTHF), a crucial coenzyme for the synthesis of DNA and RNA in the cell. MTHFD2 is a single-spored RNA enzyme with three known subunits A, B, and C. It is expressed in a variety of tissues, including muscle, liver, and brain, and is involved in the metabolism of various nucleotides, including MTHF.

MTHFD2 is a critical enzyme for the synthesis of DNA and RNA in the cell.DNA and RNA are the genetic material of the cell, and the synthesis of these molecules is essential for the replication of the cell, transcription of genetic information, and translation of RNA into proteins. MTHFD2 is involved in the synthesis of MTHF, which is then used as a template for the synthesis of DNA and RNA.

MTHFD2 is also involved in the metabolism of other nucleotides, including NAD+ (nicotinamide adenine dinucleotide), which is a crucial coenzyme for the transfer of electrons in the cell. NAD+ is involved in a variety of cellular processes, including energy metabolism, signaling, and DNA replication. MTHFD2 is a critical enzyme for the synthesis of NAD+ from MTHF, which is then used as a coenzyme in the metabolism of other nucleotides.

MTHFD2 is a protein that is expressed in a variety of tissues and is involved in the metabolism of MTHF and NAD+. It is a single-spored RNA enzyme with three known subunits A, B, and C. The subunit A is the catalytic subunit and is responsible for the catalytic activity of MTHFD2. Subunits B and C are non-catalytic subunits that play important roles in the regulation of MTHFD2 activity.

MTHFD2 is involved in the metabolism of various nucleotides, including MTHF and NAD+. It is a critical enzyme for the synthesis of DNA and RNA in the cell and is also involved in the metabolism of other nucleotides, including NAD+. As MTHFD2 is a crucial enzyme for the cell, any changes in its expression or activity can have significant implications for the cell.

One of the potential applications of MTHFD2 as a drug target is the inhibition of its activity. The inhibition of MTHFD2 activity can lead to the accumulation of MTHF and NAD+ in the cell, which can have a variety of cellular consequences. For example, the accumulation of MTHF and NAD+ can lead to an increase in the level of DNA double-strand breaks, which can lead to the development of cancer.

Another potential application of MTHFD2 as a drug target is the modulation of its activity to increase its catalytic activity. The modulation of MTHFD2 activity can be achieved through the use of small molecules, such as drugs, or through genetic modification. For example, the addition of a small molecule to the cell can inhibit the inhibition of MTHFD2 activity, leading to an increase in its catalytic activity.

MTHFD2 is also involved in the metabolism of other nucleotides, including NAD+. The inhibition of MTHFD2 activity can lead to the accumulation of NAD+ in the cell, which can have a variety of cellular consequences. For example, the accumulation of NAD+ can lead to an increase in the level of antioxidant enzymes, which can protect the cell from damage.

In conclusion, MTHFD2 (NAD-dependent methylenetetrahydrofolate dehydrogenase) is a critical enzyme involved in the metabolism of MTHF and NAD+. The inhibition of MTHFD2 activity can have

Protein Name: Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase

Functions: Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency

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