TRNI: A Potential Drug Target and Biomarker for Mitochondrial Function

Target Name: TRNI

NCBI ID: G4565

TRNI

TRNI: A Potential Drug Target and Biomarker for Mitochondrial Function

Mitochondria are critical organelles that play a vital role in the regulation of cellular processes essential for human survival. They are responsible for generating the majority of the energy for the cell through a process called cellular respiration. Mitochondria also maintain a proper balance of atoms, including nitrogen, which is essential for the synthesis of certain molecules, including tRNA isoleucine (TNL).

TRNA is a molecule that carries amino acids from the cell's amino acid pool to the ribosome during the process of translation. The most abundant tRNA is composed of a series of nucleotides called anticodons paired with amino acids. However, within cells, approximately 70% of tRNA is encoded by the mitochondria gene, known as TRNI.

TRNI is a molecule composed of nucleotides, containing an open reading frame (ORF) and a modified tRNA binding domain (MTB). ORF is the first variable region of tRNA and can encode different amino acids. MTB is a highly conserved domain located at the N-terminus of ORF that can bind amino acids on TRNA.

In recent years, research on TRNI has mainly focused on two aspects: function and the possibility of being a drug target.

The reason TRNI plays an important role in cellular metabolism is because it plays a key role in the synthesis of tRNA. tRNA is an important component of protein biosynthesis in cells. They carry amino acids, which are linked into polypeptide chains, ultimately forming proteins. Within the cell, tRNA is recycled because the cell needs to continually synthesize new proteins. However, there are various challenges during tRNA synthesis, including error rate, translation efficiency, and stability. The function of TRNI is to help cells solve these challenges and ensure the accuracy and efficiency of tRNA synthesis.

TRNI may also serve as a drug target. In cancer therapy, inhibiting TRNI function can be an effective strategy. This is because the function of TRNI is to help cells synthesize tRNA, and tRNA synthesis is necessary for the growth and survival of cancer cells. Therefore, by interfering with TRNI function, the growth and spread of cancer cells can be inhibited.

In addition, the expression level of TRNI can also be used as a biomarker to evaluate disease severity and treatment efficacy. Since TRNIs are intracellular molecules encoding tRNA, they may change during pathophysiological processes such as cell death, injury, and inflammation. By measuring TRNI expression levels, the impact of disease on cells can be assessed and whether treatment is effective.

The significance of the discovery and functional study of TRNI is that it provides a new perspective for studying cell metabolism and cancer treatment. By further studying TRNI, we can better understand the mechanism of intracellular tRNA synthesis and provide targets for the development of new drugs.

Protein Name: Mitochondrially Encoded TRNA Isoleucine

The "TRNI Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRNI comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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