TRPM2: A Protein Involved in Pain Perception and Neurological Disorders

Target Name: TRPM2

NCBI ID: G7226

TRPM2

TRPM2: A Protein Involved in Pain Perception and Neurological Disorders

TRPM2, also known as transient receptor potential channel 7, is a protein that plays a crucial role in the sense of touch and pain. It is a voltage-dependent cation channel that is expressed in many different tissues, including the skin, hair, and nervous system. TRPM2 is known for its ability to detect changes in the electrical potential of the body, which is the potential to cause pain or other sensations.

Recent studies have suggested that TRPM2 may be a drug target or biomarker for a variety of conditions, including pain, neuropathic pain, and certain neurological disorders. This is because TRPM2 is involved in the sense of touch and pain, and its activity can be modulated by various factors, including pain stimuli and certain medications.

One of the key mechanisms by which TRPM2 is involved in pain perception is its role in the development of neuropathic pain. Neuropathic pain is pain that is caused by damage to the nervous system, such as from trauma, disease, or injury. In these cases, pain signals are able to activate TRPM2, which in turn can cause the body to experience electrical sensations that can be perceived as pain.

Another potential mechanism by which TRPM2 may be involved in pain perception is its role in the modulation of pain sensitivity. Pain sensitivity is the ability of the body to experience pain, and pain sensitivity can be modulated by various factors, including the intensity of pain and the presence of other stimuli. TRPM2 has been shown to be involved in the modulation of pain sensitivity, and its activity in this system may be relevant to the development of pain disorders.

TRPM2 is also involved in the sense of touch and pressure, and its activity in this system has been studied in the context of neuropathic pain. In neuropathic pain, pain signals are able to activate TRPM2, which in turn can cause the body to experience electrical sensations that can be perceived as pain. This is similar to the way that pain signals are processed by the nervous system in general.

In addition to its role in pain perception, TRPM2 is also involved in the regulation of pain modality. Pain modality refers to the type of pain that a person experiences, such as sharp, dull, or aching. TRPM2 has been shown to be involved in the regulation of pain modality, and its activity in this system may be relevant to the development of pain disorders.

TRPM2 has also been studied in the context of neuropathic pain and other neurological disorders. For example, some studies have suggested that TRPM2 may be involved in the development of neuropathic pain in diabetes-related foot ulcers. In these cases, pain signals are able to activate TRPM2, which in turn can cause the body to experience electrical sensations that can be perceived as pain.

Another potential application of TRPM2 as a drug target or biomarker is its role in the development of certain neurological disorders, such as epilepsy and chronic pain. For example, some studies have suggested that TRPM2 may be involved in the development of epilepsy, and that its activity in this system may be modulated by certain medications.

In conclusion, TRPM2 is a protein that is involved in the sense of touch and pain. Its activity in this system can be modulated by various factors, including pain stimuli and certain medications. As a result, TRPM2 has been suggested as a potential drug target or biomarker for a variety of conditions, including pain, neuropathic pain, and certain neurological disorders. Further research is needed to fully understand the role of TRPM2 in these systems and to develop safe and effective treatments.

Protein Name: Transient Receptor Potential Cation Channel Subfamily M Member 2

Functions: Nonselective, voltage-independent cation channel that mediates Na(+) and Ca(2+) influx, leading to increased cytoplasmic Ca(2+) levels (PubMed:11960981, PubMed:12594222, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:20660597, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:28775320, PubMed:29745897, PubMed:30467180). Functions as ligand-gated ion channel (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:30467180). Binding of ADP-ribose to the cytoplasmic Nudix domain causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening (PubMed:19171771, PubMed:25620041, PubMed:28775320, PubMed:29745897, PubMed:30467180). Extracellular calcium passes through the channel and increases channel activity (PubMed:19171771). Contributes to Ca(2+) release from intracellular stores in response to ADP-ribose (PubMed:19454650). Plays a role in numerous processes that involve signaling via intracellular Ca(2+) levels (Probable). Besides, mediates the release of lysosomal Zn(2+) stores in response to reactive oxygen species, leading to increased cytosolic Zn(2+) levels (PubMed:25562606, PubMed:27068538). Activated by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Activated by intracellular ADP-ribose, beta-NAD (NAD(+)) and similar compounds, and by oxidative stress caused by reactive oxygen or nitrogen species (PubMed:11960981, PubMed:11385575, PubMed:11509734, PubMed:11804595, PubMed:15561722, PubMed:16601673, PubMed:19171771, PubMed:25620041, PubMed:27383051, PubMed:27068538, PubMed:30467180). The precise physiological activators are under debate; the true, physiological activators may be ADP-ribose and ADP-ribose-2'-phosphate (PubMed:20650899, PubMed:25918360). Activation by ADP-ribose and beta-NAD is strongly increased by moderate heat (35 to 40 degrees Celsius) (PubMed:16601673). Likewise, reactive oxygen species lower the threshold for activation by moderate heat (37 degrees Celsius) (PubMed:22493272). Plays a role in mediating behavorial and physiological responses to moderate heat and thereby contributes to body temperature homeostasis. Plays a role in insulin secretion, a process that requires increased cytoplasmic Ca(2+) levels (By similarity). Required for normal IFNG and cytokine secretion and normal innate immune immunity in response to bacterial infection. Required for normal phagocytosis and cytokine release by macrophages exposed to zymosan (in vitro). Plays a role in dendritic cell differentiation and maturation, and in dendritic cell chemotaxis via its role in regulating cytoplasmic Ca(2+) levels (By similarity). Plays a role in the regulation of the reorganization of the actin cytoskeleton and filopodia formation in response to reactive oxygen species via its role in increasing cytoplasmic Ca(2+) and Zn(2+) levels (PubMed:27068538). Confers susceptibility to cell death following oxidative stress (PubMed:12594222, PubMed:25562606)

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