PAPPA: Key Regulator of Blood-Brain Barrier and Many Other Cellular Processes

Target Name: PAPPA

NCBI ID: G5069

PAPPA

PAPPA: Key Regulator of Blood-Brain Barrier and Many Other Cellular Processes

PAPPA (PAPP-A) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a key regulator of the blood-brain barrier, which is a specialized barrier that separates the brain from the rest of the body and helps to protect it from harmful substances.

PAPPA is composed of several subunits that are held together by disulfide bonds. This structure allows the subunits to move and interact with each other, allowing PAPPA to form a complex structure that is involved in many different cellular processes.

One of the key functions of PAPPA is its role in regulating the movement of cells through the blood-brain barrier. This barrier is made up of tight junctions, which are specialized Gap channels that allow certain molecules to come and go in and out of the brain. PAPPA helps to regulate the strength and stability of these channels, allowing cells to come and go as needed while keeping others out.

In addition to its role in regulating the blood-brain barrier, PAPPA is also involved in many other cellular processes. For example, it is a key regulator of the production of new blood vessels, which is important for the delivery of oxygen and nutrients to the brain. It is also involved in the regulation of ion channels, which are important for the flow of electrical signals in the brain.

PAPPA is a protein that is expressed in many different tissues throughout the body, and it is involved in many important cellular processes. Its role in regulating the blood-brain barrier and its involvement in the production of new blood vessels and the regulation of ion channels make it a potential drug target. Further research is needed to fully understand the functions of PAPPA and its potential as a drug.

Protein Name: Pappalysin 1

Functions: Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF

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•   general information;
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