PLP: Transmembrane Protein with Multiple Functions (G51090)

Target Name: PLLP

NCBI ID: G51090

PLLP

PLP: Transmembrane Protein with Multiple Functions

Plasmolipin (PLP) is a transmembrane protein belonging to the PPLP (transmembrane 4 superfamily member 11) family. It is a 28-kDa protein that is expressed in various tissues, including brain, heart, liver, and kidney. PLP has been shown to play a crucial role in various physiological processes, including cell signaling, cell adhesion, and cell survival.

PLP is composed of four domains: an N-terminal transmembrane domain, a catalytic domain, a C-terminal cytoplasmic domain, and a unique N-terminal cytoplasmic region. The N-terminal transmembrane domain is responsible for PLP's transmembrane properties, while the catalytic domain is involved in its catalytic activity. The C-terminal cytoplasmic domain is responsible for PLP's ability to interact with various cellular signaling pathways.

PLP has been shown to play a role in various signaling pathways, including the sonic hedgehog pathway, the TGF-β pathway, and the Wnt signaling pathway. In the sonic hedgehog pathway, PLP has been shown to regulate the activities of the Smad transcription factors, which are involved in cell signaling.

PLP has also been shown to play a role in cell adhesion and cell survival. For example, PLP has been shown to interact with the adhesion molecule E-cadherin and promote its association with E-cadherin. This interaction between PLP and E-cadherin is important for the proper functioning of cell-cell adhesion and for the development of various diseases, such as cancer.

PLP has also been shown to play a role in various cellular signaling pathways that are involved in cell survival. For example, PLP has been shown to interact with the B-cell receptor (BCR), which is involved in the development and function of B cells. This interaction between PLP and BCR is important for the proper functioning of B cell development and for the development of various diseases, such as leukemia.

In conclusion, PLP is a transmembrane protein that plays a crucial role in various physiological processes. Its unique structure and various functions make it an attractive drug target and a potential biomarker for various diseases. Further research is needed to fully understand the role of PLP in various biological processes and to develop effective therapies for the treatment of PLP-related diseases.

Protein Name: Plasmolipin

Functions: Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity)

The "PLLP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLLP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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