PLPP1: Key Enzyme in Lipid Metabolism (G8611)

Target Name: PLPP1

NCBI ID: G8611

PLPP1

PLPP1: Key Enzyme in Lipid Metabolism

PLPP1 (Lipid phosphate phosphohydrolase 1) is a protein that is expressed in various cell types, including bacteria, yeast, plants, and animals. It is a key enzyme in the lipid metabolism pathway, which is involved in the breakdown of lipids into simpler components for energy production.

PLPP1 is a single-stranded transmembrane protein that consists of 254 amino acids. It has a catalytic active site, a catalytic loop, and a C-terminus. The catalytic active site is the region that binds with other molecules, such as phosphate groups, which are essential for its function.

PLPP1 is a critical enzyme in the lipid metabolism pathway. It catalyzes the breakdown of triacylglycerols (triglycerides) into simpler components, such as fatty acids and glycerol. This process is essential for the production of energy in the form of ATP and for the maintenance of cellular membrane structure.

PLPP1 is also involved in the synthesis of various lipids, including phospholipids, which are important components of cell membranes. It is also involved in the degradation of various lipids, such as triacylglycerols that have become damaged or are no longer needed.

In addition to its role in lipid metabolism, PLPP1 is also a potential drug target. Several studies have suggested that inhibiting PLPP1 may be a useful strategy for treating various diseases, including obesity, diabetes, and cardiovascular disease.

One of the reasons for PLPP1's potential as a drug target is its involvement in the production of fatty acids, which can contribute to the development of obesity and other metabolic disorders. Obesity is a condition that is characterized by an excess of body fat, which can increase the risk of various diseases, including cardiovascular disease and diabetes.

In addition to its role in the production of fatty acids, PLPP1 may also be involved in the regulation of cellular signaling pathways. Several studies have suggested that PLPP1 is involved in the regulation of various signaling pathways, including the TGF-β pathway, which is involved in cell growth and differentiation.

PLPP1 is also involved in the regulation of cellular signaling pathways that are involved in inflammation and immune responses. Several studies have suggested that PLPP1 is involved in the regulation of various signaling pathways, including the NF-kappa-B pathway, which is involved in inflammation and immune responses. responses.

In addition to its potential as a drug target, PLPP1 is also an attractive biomarker for the diagnosis and monitoring of various diseases. Several studies have suggested that changes in PLPP1 activity or expression levels may be associated with the development of various diseases, including obesity, diabetes, and cardiovascular disease.

In conclusion, PLPP1 is a key enzyme in the lipid metabolism pathway that is involved in the production of fatty acids, the regulation of cellular signaling pathways, and the regulation of cellular signaling pathways that are involved in inflammation and immune responses. Its potential as a drug target and as a biomarker for the diagnosis and monitoring of various diseases makes it an attractive target for further research.

Protein Name: Phospholipid Phosphatase 1

Functions: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599). Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (PubMed:9607309). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599). It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599). Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590). May also have an intracellular activity to regulate phospholipid-mediated signaling pathways (By similarity)

The "PLPP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLPP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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