PHF11: A Potential Drug Target for Neurological Disorders (G51131)

Target Name: PHF11

NCBI ID: G51131

PHF11

PHF11: A Potential Drug Target for Neurological Disorders

PHF11 (NYREN34) is a protein that is expressed in the brain and is known for its role in the regulation of cell survival and proliferation. It is a potential drug target for various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression.

PHF11 is a member of the PHF1 family, which includes several similar proteins that are expressed in various tissues throughout the body. These proteins are known as PHF11 homologs (PHF11Hs) and are involved in the regulation of cellular processes such as cell adhesion, migration, and survival.

PHF11 is expressed in the brain and is involved in the regulation of various brain cell functions, including the formation and maintenance of neural networks, the regulation of neurotransmitter release, and the control of cell survival. It is also involved in the regulation of immune cell function and has been implicated in the development of neuroimmune disorders.

One of the key functions of PHF11 is its role in the regulation of cell survival and proliferation. PHF11 has been shown to play a role in the regulation of cell cycle progression, by preventing the formation of deep peripheral spindle structures (maturation centrioles body). This structure is the centrosome of the cell cycle and is involved in the cell division process. By preventing the formation of deep peripheral spindle structures during the cell cycle, PHF11 extends cell lifespan and promotes cell proliferation.

In addition, PHF11 is also involved in the regulation of apoptosis. Apoptosis is an important way of cell death and plays an important role in the survival and regeneration of neurons. Studies have shown that PHF11 can regulate apoptosis, thereby affecting neuronal injury and treatment response.

Abnormal expression of PHF11 is closely related to the occurrence and development of various neurological diseases. For example, abnormal expression of PHF11 in Alzheimer's disease has been shown to be associated with neuronal damage and neuronal death. In one study, scientists found that knockdown of the PHF11 gene could significantly reduce the degree of neuronal damage in patients with Alzheimer's disease, thereby improving the patients' cognitive function and quality of life.

In addition, abnormal expression of PHF11 is closely related to the occurrence and development of depression. Studies have shown that increased PHF11 gene expression levels are associated with the appearance and severity of negative emotions in patients with depression. These findings provide a new target for the treatment of depression.

Taken together, PHF11 is a promising drug target for the treatment of various neurological and psychiatric disorders. By regulating cell survival and apoptosis, as well as participating in nervous system development and function, PHF11 can improve patients' clinical manifestations and quality of life. Future research will continue to further explore the role of PHF11 in neurological diseases and explore its clinical application value.

Protein Name: PHD Finger Protein 11

Functions: Positive regulator of Th1-type cytokine gene expression

The "PHF11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PHF11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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