TMEM119: A Transmembrane Protein for Drug Targets and Biomarkers

Target Name: TMEM119

NCBI ID: G338773

TMEM119

TMEM119: A Transmembrane Protein for Drug Targets and Biomarkers

TMEM119 (Transmembrane Protein 119) is a protein that has been identified as a potential drug target and biomarker. It is a member of the transmembrane protein (TMEM) family, which are a diverse group of proteins that span various cellular processes, including signaling, ion transport, and structural integrity. TMEM119 has been shown to play a critical role in the regulation of cellular processes, including cell adhesion, migration, and the regulation of ion channels.

The Druggability of TMEM119

TMEM119 is a small molecule protein that can be easily modified to serve as a drug or biomarker. Its unique structure and subcellular localization make it an attractive target for small molecule inhibitors. TMEM119 is a monomeric protein that consists of an N-terminus, a catalytic C-terminus, and a C-terminal transmembrane region. It has a calculated pI of 6.5 and a calculated molecular weight of 11.4 kDa. TMEM119 is highly conserved in various species, with a sequence identity of 64% among human, mouse, and human heart proteins.

TMEM119 has been shown to be involved in various cellular processes, including cell adhesion, migration, and the regulation of ion channels. It is a critical regulator of the migration of cancer cells to new tissues, and has been implicated in the development of various diseases, including cancer. TMEM119 has also been shown to play a role in the regulation of ion channels, which are critical for the maintenance of cellular electrical potential. The regulation of ion channels is critical for maintaining the integrity of the cell membrane, and is involved in various cellular processes, including muscle contractions, nerve function, and brain activity.

The potential drug targeting of TMEM119 is derived from its unique structure and subcellular localization. TMEM119 is a transmembrane protein that is primarily expressed in the endoplasmic reticulum (ER) and is highly conserved in various species. Its unique structure and subcellular localization make it an attractive target for small molecule inhibitors. TMEM119 has been shown to have a high degree of cross-reactivity, which means that it can be inhibited by a variety of small molecules.

TMEM119 has also been shown to have a unique mechanism of inhibition. TMEM119 is a N-terminal-only protein that is primarily expressed in the ER. It has been shown that TMEM119 can be inhibited by small molecules that are specific to the N-terminus of TMEM119. This mechanism of inhibition is unique because it is not dependent on the overall structure or function of TMEM119.

The potential biomarker potential of TMEM119 is derived from its unique structure and subcellular localization. TMEM119 is a transmembrane protein that is primarily expressed in the ER and has been shown to play a critical role in the regulation of cellular processes, including cell adhesion, migration, and the regulation of ion channels. Its unique structure and subcellular localization make it an attractive target for small molecule inhibitors and biomarkers.

Conclusion

TMEM119 is a unique protein that has been identified as a potential drug target and biomarker. Its unique structure and subcellular localization make it an attractive target for small molecule inhibitors. TMEM119 has been shown to play a critical role in the regulation of cellular processes, including cell adhesion, migration, and the regulation of ion channels. Its unique mechanism of inhibition and its potential as a drug target and biomarker make TMEM119 a promising target for small molecule inhibitors. Further research is needed to fully understand the

Protein Name: Transmembrane Protein 119

Functions: Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity)

The "TMEM119 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM119 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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