TMEM126A: A Transmembrane Protein with Potential as a Drug Target or Biomarker

Target Name: TMEM126A

NCBI ID: G84233

TMEM126A

TMEM126A: A Transmembrane Protein with Potential as a Drug Target or Biomarker

Introduction

TMEM126A, a member of the transmembrane protein (TMEM) family, has been identified as a potential drug target and biomarker. TMEM proteins are involved in various cellular processes, including cell signaling, chromosome structure, and neurotransmission. The function and dysfunction of TMEM126A have has been extensively studied, and its potential as a drug target or biomarker continues to attract researchers' interest.

background:

TMEM126A is a protein located on the cell membrane and belongs to the TMEM family. TMEM proteins are involved in a variety of cellular processes, including cell signaling, chromosome structure, and neurotransmission. The function and dysregulation of TMEM126A have been extensively studied, and its potential as a drug target or biomarker continues to attract the attention of researchers.

Structure and function of TMEM126A

TMEM126A is a transmembrane protein whose main function is to participate in the signaling process inside and outside the cell. TMEM126A consists of 126 amino acids and has a molecular weight of 18.5 kilodaltons. TMEM126A has a transmembrane domain and two intracellular domains. The transmembrane region includes a catalytic domain, a transmembrane region, and a cytoplasmic region.

The catalytic domain of TMEM126A is a conserved threonine-phenylalanine-aspartate (Ser-Phe-Asp) core, which is considered to be the main functional domain of TMEM126A. The catalytic domain of TMEM126A is highly conserved, and the amino acids conserved in multiple species have similar chemical properties. These conserved amino acids may play a key role in the function of TMEM126A.

The intracellular region of TMEM126A includes an N-terminal 伪-helix, a central 尾-sheet, and a C-terminal domain. The N-terminal 伪-helix is 鈥嬧?媡he most striking feature in the intracellular domain of TMEM126A. The N-terminal 伪-helix of TMEM126A has a unique secondary structure, including a unique helix height and a conserved hydrogen bond.

TMEM126A functions

TMEM126A plays an important role in various physiological processes. In cell division, the catalytic domain of TMEM126A is involved in the assembly and depolymerization of the mitotic spindle. During cell migration, the catalytic domain of TMEM126A participates in signal transduction inside and outside the cell, thereby regulating cell migration. In addition, TMEM126A is also involved in intracellular metabolic processes, including glucose and fatty acid metabolism.

Pharmacological significance of TMEM126A

The pharmacological significance of TMEM126A is that, as a drug target, it may have an important impact on a variety of diseases. Currently, researchers are exploring whether TMEM126A has potential as a therapeutic agent for anti-tumor, anti-inflammatory and anti-neurodegenerative diseases.

TMEM126A can also be used as a biomarker to detect the progression and treatment efficacy of various diseases. For example, TMEM126A can be used to detect the progression and treatment effects of skin cancer, breast cancer, lung cancer and other cancers. In addition, TMEM126A can also be used as a biomarker for neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and other diseases.

Clinical application of TMEM126A

Although the clinical application of TMEM126A as a drug target or biomarker is still in the exploratory stage, it provides a new idea for the treatment of various diseases. Researchers are exploring whether TMEM126A could serve as an effective therapeutic for treating a variety of diseases, such as tumors, inflammation, and neurodegenerative diseases

Protein Name: Transmembrane Protein 126A

The "TMEM126A Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM126A comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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