TMEM132A: A Transmembrane Protein of Unconventional Significance

Target Name: TMEM132A

NCBI ID: G54972

TMEM132A

TMEM132A: A Transmembrane Protein of Unconventional Significance

TMEM132A, also known as Transmembrane protein 132A (isoform b), is an essential protein that plays a vital role in various physiological processes in the human body. It is a member of the superfamily of transmembrane proteins, which are a class of proteins that span the membrane of the cell and extend into the cytoplasm or the space between cells. TMEM132A is a unique protein because of its unusual structure, localization, and function.

Structure and Localization

TMEM132A is a 21-kDa protein that consists of 118 amino acid residues. It has a unique transmembrane structure, with a cytoplasmic region that is formed by a single amino acid residue, a catalytic domain, and a carboxylic acid region that is located at the cytoplasmic side of the membrane. The protein has a pre-伪 and pre-尾 regions, which are located at the opposite ends of the cytoplasmic region.

TMEM132A is primarily localized to the cytoplasm, where it is involved in various cellular processes, including the regulation of ion and solute transport, as well as the maintenance of cell structure and the production of lysosomes. The protein is also expressed in the endoplasmic reticulum (ER) and is involved in the regulation of protein traffic, which is critical for maintaining cellular homeostasis.

Function

TMEM132A is involved in several essential cellular processes that are critical for the survival of the cell. One of its most significant functions is its role in the regulation of ion and solute transport. The cytoplasmic region of TMEM132A contains a unique ion-selective channel that is responsible for the rapid and efficient transport of ions and solutes across the membrane. This function is critical for maintaining the proper levels of ions in the cell, which are essential for various cellular processes, including muscle contractions, nerve signals, and cell signaling.

In addition to its role in ion and solute transport, TMEM132A is also involved in the regulation of cell structure and the production of lysosomes. The pre-伪 and pre-尾 regions of the protein contain unique domains that are involved in the regulation of cell shape and the formation of lysosomes, which are important for the degradation of damaged or unnecessary cellular components.

TMEM132A is also involved in the regulation of protein traffic, which is critical for maintaining cellular homeostasis. The protein is known to interact with several other transmembrane proteins, including the transmembrane protein ZNF217 and the cytoplasmic protein TPM1. These interactions are important for the proper delivery ofTMEM132A to its localization and for the regulation of its function.

Drug Target Potential

TMEM132A is a drug target of great interest because of its unique structure and function. The cytoplasmic region of the protein has a unique channel that is involved in the rapid and efficient transport of ions and solutes across the membrane, which makes it an attractive target for small molecules that can modulate ion and solute transport. In addition, the protein has been shown to play a critical role in the regulation of cell shape and the formation of lysosomes, which makes it an attractive target for drugs that can modulate these processes.

TMEM132A is also a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The protein is known to be expressed in various tissues and organs, including the brain, pancreas, and liver, which makes it an attractive target for diagnostic tests that can detect the protein in these tissues

Protein Name: Transmembrane Protein 132A

Functions: May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation (By similarity)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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