TMEM117: A Transmembrane Protein of Unusual Structure and Potential Drug Target

Target Name: TMEM117

NCBI ID: G84216

TMEM117

TMEM117: A Transmembrane Protein of Unusual Structure and Potential Drug Target

Introduction

TMEM117, also known as transmembrane protein 117, is a protein that localizes to the endoplasmic reticulum (ER) and is involved in various cellular processes, including cell signaling, protein transport, and cell survival. Its unique structure, which consists of a long transmembrane region and a cytoplasmic tail, has led to a high degree of interest in its potential as a drug target or biomarker.

Structure and Function

The TMEM117 protein is approximately 400 amino acids long and has a unique transmembrane structure. It consists of a long N-terminal cytoplasmic region, a transmembrane region, and a C-terminal cytoplasmic region. The transmembrane region is characterized by a single transmembrane 伪 -Helix, which is responsible for the protein's stability and localization to the ER.

The TMEM117 protein plays a critical role in the delivery of proteins to the ER. It is involved in the formation of the endoplasmic reticulum-associated vesicle (ERV), which is a structure that surrounds the ER and is involved in the transport of proteins to the Golgi system. TMEM117 is also involved in the subsequent transport of proteins from the ER to the cytosol, where they can be involved in various cellular processes.

In addition to its role in protein transport, TMEM117 is also involved in cell signaling. It has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. TMEM117 has been shown to interact with various cellular signaling pathways, including the TGF-β pathway, which is involved in cell growth, survival, and angiogenesis.

TMEM117 has also been shown to play a role in the regulation of cellular signaling pathways that are involved in cell survival. It has been shown to interact with the protein p53, which is a well-known tumor suppressor protein. TMEM117 has been shown to play a role in the regulation of p53 function, which may ultimately lead to the inhibition of cell growth and the regulation of cell death.

TMEM117 has also been shown to play a role in the regulation of the Wnt signaling pathway, which is involved in the regulation of cell growth and development. It has been shown to interact with the protein Wnt, which is a key transcription factor involved in the regulation of cellular processes that are involved in cell growth and development.

TMEM117 has also been shown to play a role in the regulation of the Notch signaling pathway, which is involved in the regulation of cell survival and proliferation. It has been shown to interact with the protein Notch, which is a transmembrane protein that is involved in the regulation of cellular processes that are involved in cell survival and proliferation.

Drug Targeting and Biomarker Potential

The unique structure of TMEM117, which consists of a long transmembrane region and a cytoplasmic tail, has led to a high degree of interest in its potential as a drug target. Several studies have shown that TMEM117 can be targeted by small molecules, including inhibitors of tyrosine kinase activity and inhibitors of the interaction between TMEM117 and various signaling proteins.

One of the most promising TMEM117 drug targets is the protein p53, which is a well-known tumor suppressor protein. Several studies have shown that inhibitors of p53 function can be used to inhibit the of p53 by TMEM117, which may ultimately lead to the regulation inhibition of cell growth and the regulation of cell death.

Another promising TMEM117 drug target is the protein

Protein Name: Transmembrane Protein 117

Functions: Involved in endoplasmic reticulum (ER) stress-induced cell death pathway

The "TMEM117 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM117 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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