TMEM131: A Transmembrane Protein with High Potential as a Drug Target or Biomarker

Target Name: TMEM131

NCBI ID: G23505

TMEM131

TMEM131: A Transmembrane Protein with High Potential as a Drug Target or Biomarker

TMEM131, also known as transmembrane protein 131, is a protein that is expressed in various tissues and organs in the human body. Its primary function is to regulate the movement of water and solutes across the cell membrane. TMEM131 plays a crucial role in maintaining the proper balance of water and solutes in the cells, which is essential for maintaining cellular homeostasis.

Recent studies have suggested that TMEM131 may have potential as a drug target or biomarker. In this article, we will explore the biology and potential applications of TMEM131 in more detail.

Biogenesis and Localization

TMEM131 is a member of the Tmem1 family, which includes several other transmembrane proteins that play similar functions in various organisms. The Tmem1 family is characterized by the presence of a transmembrane domain, a cytoplasmic tail, and a N-terminus that is involved in protein-protein interactions.

TMEM131 is predominantly expressed in the brain, heart, and kidneys, where it is involved in regulating the movement of water and solutes across the cell membrane. It is also expressed in other tissues, including the liver, pancreas, and red blood cells. TMEM131 is primarily localized to the cytoplasm of the cells, and its concentration is highest in the brain.

Function and Potential Applications

Several studies have suggested that TMEM131 may have potential as a drug target or biomarker. One of the main functions of TMEM131 is to regulate the movement of water and solutes across the cell membrane. This is essential for maintaining the proper balance of water and solutes in the cells, which is critical for maintaining cellular homeostasis.

In addition to its role in regulating the movement of water and solutes, TMEM131 has also been shown to play a role in several other processes in the body. For example, it has been shown to be involved in the regulation of ion and water transport in the kidneys. It is also involved in the regulation of the production of new blood cells in the bone marrow.

In recent years, researchers have been interested in using TMEM131 as a drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and kidney diseases. One of the main reasons for this interest is the fact that TMEM131 has been shown to be overexpressed or underexpressed in many diseases, which can make it a useful target for researchers to study the effects of drugs on TMEM131 expression and function.

Drug Interactions with TMEM131

Several studies have shown that TMEM131 can be targeted by small molecules, including inhibitors of tyrosine kinase activity and inhibitors of voltage-dependent ion channels. These molecules have been shown to reduce the expression of TMEM131 and increase its degradation in the cells.

One of the most promising compounds that has been shown to interact with TMEM131 is a small molecule called U-87120, which is an inhibitor of the tyrosine kinase activity of TMEM131. U-87120 has been shown to reduce the expression of TMEM131 in cancer cells and improve the sensitivity of these cells to chemotherapy.

Another compound that has been shown to interact with TMEM131 is a small molecule called TPM-1, which is a inhibitor of

Protein Name: Transmembrane Protein 131

Functions: May play a role in the immune response to viral infection

The "TMEM131 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM131 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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