Target Name: MBTPS2
NCBI ID: G51360
Review Report on MBTPS2 Target / Biomarker Content of Review Report on MBTPS2 Target / Biomarker
MBTPS2
Other Name(s): Sterol regulatory element-binding proteins intramembrane protease | KFSDX | Membrane bound transcription factor peptidase, site 2 | keratosis follicularis spinulosa decalvans | SREBPs intramembrane protease | MBTP2_HUMAN | BRESEK | S2P protein | sterol regulatory element-binding proteins intramembrane protease | endopeptidase S2P | site-2 protease | membrane-bound transcription factor protease, site 2 | Membrane-bound transcription factor site-2 protease | Site-2 protease | membrane bound transcription factor peptidase, site 2 | Endopeptidase S2P | S2P | OLMSX | IFAP | KFSD | Membrane-bound transcription factor protease, site 2 | OI19

MBTPS2: A Potential Drug Target and Biomarker for Sterol Regulatory Element-Binding Proteins

Sterol regulatory element-binding proteins (SREBP) are a family of transmembrane proteins that play a crucial role in maintaining cellular membrane fluidity and stability. They are involved in a wide range of cellular processes, including cellular signaling, DNA replication, and inflammation. MBTPS2 , a protein that belongs to the SREBP family, is an intracellular protease that is involved in the regulation of sterol levels in the cell.

MBTPS2 is a 25-kDa protein that is expressed in various cell types, including neurons, liver cells, and peripheral blood cells. It is localized to the endoplasmic reticulum (ER) and cytoplasm and is involved in the degradation of sterols, such as 2 -oleoyl-sn-coa desterylase (2-OS) and farnesyl-protein thiokinase (FPT), which are critical for the synthesis of sterols.

Sterols are important molecules that regulate various cellular processes, including cell signaling, DNA replication, and inflammation. They are involved in the formation of the cell membrane, and their levels are carefully regulated to maintain the appropriate level of fluidity and stability. The synthesis of sterols from the starting material, such as 2-OS and FPT, is a critical step in the sterol regulatory pathway. MBTPS2 is involved in the regulation of this step by degrading sterols, which is crucial for maintaining the cellular membrane stability and integrity.

MBTPS2 has been shown to play a crucial role in the regulation of sterol levels in various cell types. For example, studies have shown that MBTPS2 is involved in the regulation of 2-OS and FPT levels in cancer cells. In addition, MBTPS2 has been shown to play a role in the regulation of sterol levels in the brain, where it is involved in the development and maintenance of the neuronal cell membrane.

MBTPS2 is also involved in the regulation of other cellular processes, including cell signaling, DNA replication, and inflammation. For example, studies have shown that MBTPS2 is involved in the regulation of the levels of phosphorylcholine in the cell, which is an important signaling molecule involved in cell signaling. In addition, MBTPS2 is involved in the regulation of the levels of reactive oxygen species (ROS) in the cell, which are important indicators of cellular stress and inflammation.

MBTPS2 is also involved in the regulation of the levels of various enzymes involved in the sterol regulatory pathway, including FPT, 2-OS, and sterol lipid binding proteins (SLBP). These enzymes are critical for the synthesis and degradation of sterols, and their levels are regulated by MBTPS2.

MBTPS2 has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. For example, studies have shown that MBTPS2 is involved in the regulation of the levels of 2-OS and FPT in cancer cells, which are critical for the development and progression of cancer. In addition, MBTPS2 has been shown to play a role in the regulation of the levels of FPT and SLBP in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

MBTPS2 is also involved in the regulation of the levels of various signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell signaling and is critical for the development and maintenance of tissues and organs.

In conclusion, MBTPS2 is a protein that is involved in the regulation of sterol levels in the cell. It is a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular disease. Further research is needed to fully understand the role of MBTPS2 in

Protein Name: Membrane Bound Transcription Factor Peptidase, Site 2

Functions: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209, PubMed:10805775). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached (PubMed:10805775, PubMed:27380894, PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775, PubMed:27380894, PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894)

The "MBTPS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MBTPS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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