PDHA1: A Potential Drug Target for Energy and Cellular Processes

Target Name: PDHA1

NCBI ID: G5160

PDHA1

PDHA1: A Potential Drug Target for Energy and Cellular Processes

PDHA1 (Pyruvate dehydrogenase E1 subunit alpha 1, transcript variant 1) is a protein that plays a crucial role in the metabolism of pyruvate, a critical fuel for cellular energy production. PDHA1 is a subunit of the PDH complex, which is a complex of enzymes involved in the citric acid cycle, also known as the Krebs cycle or TCA cycle.

PDHA1 is a 21-kDa protein that consists of 116 amino acid residues. It is expressed in most tissues and is involved in the final step of the citric acid cycle, which is the production of ATP from pyruvate.

PDHA1 functions as a catalytic subunit of the PDH complex, where it interacts with the subunits Pyruvate Transcarrier Protonase (PTP) and Pyruvate Dehydrogenase (PDH) to produce ATP and carbon dioxide. The catalytic activity of PDHA1 is critical for the rate of the citric acid cycle and therefore for the overall energy production in the cell.

PDHA1 has been identified as a potential drug target due to its involvement in the citric acid cycle and the potential impact on cellular energy production. Studies have shown that inhibiting PDHA1 activity can lead to a decrease in the rate of the citric acid cycle and a corresponding decrease in cellular energy production.

In addition to its role in energy metabolism, PDHA1 is also involved in the regulation of cellular processes such as cell adhesion, migration and invasion.

PDHA1 has been shown to play a role in the regulation of cell adhesion and migration. For example, PDHA1 has been shown to interact with the protein N-cadherin, which is a protein that helps to maintain cell-cell adhesion. This interaction between PDHA1 and N-cadherin suggests that PDHA1 may be involved in the regulation of cell-cell adhesion.

PDHA1 has also been shown to be involved in the regulation of cell migration and invasion. For example, studies have shown that PDHA1 is involved in the regulation of the migration of cancer cells. This interaction between PDHA1 and cell migration may be a potential therapeutic target for cancer treatment.

PDHA1 is also involved in the regulation of many cellular processes, including cell signaling, DNA replication and repair, and metabolism.

PDHA1 is involved in the regulation of cell signaling, for example, it has been shown to interact with the protein kinase A3 (PKA3), which is involved in cell signaling. This interaction between PDHA1 and PKA3 suggests that PDHA1 may be involved in the regulation of cell signaling.

PDHA1 is also involved in the regulation of DNA replication and repair. For example, studies have shown that PDHA1 is involved in the regulation of DNA replication, which is a critical process for cell growth and division.

PDHA1 is also involved in the regulation of metabolism, for example, it has been shown to interact with the protein Pyruvate Carrier Protonase (PCP), which is involved in the production of ATP from pyruvate. This interaction between PDHA1 and PCP suggests that PDHA1 may be involved in the regulation of metabolism.

In conclusion, PDHA1 is a protein that plays a crucial role in the metabolism of pyruvate and the production of ATP from pyruvate. PDHA1 is also involved in the regulation of cell adhesion, migration and invasion and many cellular processes including cell signaling, DNA replication and repair, and metabolism. These properties make PDHA1 a potential drug target. The inhibition of PDHA1 activity may have

Protein Name: Pyruvate Dehydrogenase E1 Subunit Alpha 1

Functions: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle

The "PDHA1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PDHA1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets