PDHX: Key Regulator of Neuronal Communication and Microtubules

Target Name: PDHX

NCBI ID: G8050

PDHX

PDHX: Key Regulator of Neuronal Communication and Microtubules

PDHX, also known as PDHX variant 2, is a protein that is expressed in the brain and is involved in the development and maintenance of neuronal communication. It is a key regulator of the microtubules, which are the structural elements that transports vesicles of neurotransmitters and enables synaptic communication between neurons.

PDHX is a 14 kDa protein that consists of two main isoforms, PDHX-伪 and PDHX-尾. These isoforms differ in their length and their localization to different brain regions. PDHX-伪 is predominantly expressed in the cerebellum, while PDHX-尾 is predominantly expressed in the brainstem.

PDHX is involved in the regulation of many different cellular processes in the brain, including neuronal communication, neurotransmitter release, and synaptic plasticity. It is a key regulator of the formation and maintenance of the microtubules, which are the structural elements that transports vesicles of neurotransmitters and enables synaptic communication between neurons.

PDHX is also involved in the regulation of the dynamics of the microtubules. Studies have shown that PDHX-伪 and PDHX-尾 can interact with each other to regulate the stability of the microtubules. Additionally, PDHX can interact with other proteins involved in the regulation of microtubule dynamics, such as the protein T-tubulin.

PDHX is also involved in the regulation of the organization of the neurons in the brain. Research shows that PDHX-伪 is involved in the regulation of neuronal dendrites and the organization of the neurons in the cerebellum. PDHX-尾, on the other hand, is involved in the regulation of neuronal synapses and the organization of the neurons in the brainstem.

PDHX is also involved in the regulation of the neurotransmitter release from the neurons. Studies have shown that PDHX-伪 and PDHX-尾 can interact with each other to regulate the release of neurotransmitters from neurons. Additionally, PDHX can interact with other proteins involved in the regulation of neurotransmitter release, such as the protein neurotrophin.

PDHX is also involved in the regulation of synaptic plasticity. Studies have shown that PDHX-伪 and PDHX-尾 can interact with each other to regulate the formation and stability of synaptic plasticity. Additionally, PDHX can interact with other proteins involved in the regulation of synaptic plasticity, such as the protein strengthening factors.

In conclusion, PDHX is a protein that is expressed in the brain and is involved in the development and maintenance of neuronal communication. It is a key regulator of the microtubules, which are the structural elements that transports vesicles of neurotransmitters and enables synaptic communication between neurons . Additionally, PDHX is involved in the regulation of many different cellular processes in the brain, including neuronal communication, neurotransmitter release, and synaptic plasticity. Therefore, PDHX is a potential drug target and a biomarker for various neurological disorders.

Protein Name: Pyruvate Dehydrogenase Complex Component X

Functions: Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex

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