PDK4: A Potential Drug Target for Metabolic Disorders (G5166)

Target Name: PDK4

NCBI ID: G5166

PDK4

Other Name(s): Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial | pyruvate dehydrogenase kinase 4 | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial | pyruvate dehydrogenase kinase, isoenzyme 4 | pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial | PDK4_HUMAN | Pyruvate dehydrogenase kinase isoform 4 | Pyruvate dehydrogenase kinase 4 | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

PDK4: A Potential Drug Target for Metabolic Disorders

PDK4, or Pyruvate Dehydrogenase Lipoamide Kinase Isozyme 4, is a protein that is located in the mitochondria. It plays a crucial role in the metabolism of lipids, which are an essential component of the body. Lipids are the building blocks of all cells and are responsible for maintaining energy levels, insulation, and the structure of cell membranes.

PDK4 is a key enzyme that participates in lipid metabolism, specifically the breakdown of fatty acids and the addition of these acids to the mitochondria to produce energy. It is a critical enzyme for the transport of fatty acids into the mitochondria and for the production of the ketone bodies, which are important for energy metabolism.

PDK4 is also involved in the regulation of lipid synthesis and breakdown. It is known to interact with the transcription factor, PPAR未 (peroxisome proliferator-activated receptor delta), which regulates lipid metabolism. This interaction between PDK4 and PPAR未 suggests that PDK4 may be a potential drug target for the treatment of various metabolic disorders that are characterized by abnormal lipid metabolism.

In addition to its role in lipid metabolism, PDK4 is also a potential biomarker for several diseases. For example, it is has been shown to be elevated in individuals with heart disease, which may indicate that it is a potential diagnostic marker for this disease. Additionally, PDK4 has been shown to be elevated in individuals with type 2 diabetes, which may indicate that it is a potential diagnostic or therapeutic target for this disease.

PDK4 is also a potential drug target for the treatment of obesity. Obesity is a disease that is characterized by an abnormal amount of body fat, which can lead to a number of health problems, including heart disease, diabetes, and certain cancers. PDK4 may be a potential target for the treatment of obesity because it is involved in the metabolism of fat and is thought to play a role in the regulation of lipid storage.

In conclusion, PDK4 is a protein that is located in the mitochondria and plays a crucial role in the metabolism of lipids. It is a potential drug target for the treatment of various metabolic disorders, including heart disease, type 2 diabetes, and obesity. Further research is needed to fully understand the role of PDK4 in lipid metabolism and to determine its potential as a drug target.

Protein Name: Pyruvate Dehydrogenase Kinase 4

Functions: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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