TRNAU1AP: A Protein Involved in Regulating TRNA Stability and Translation Efficiency

Target Name: TRNAU1AP

NCBI ID: G54952

TRNAU1AP

TRNAU1AP: A Protein Involved in Regulating TRNA Stability and Translation Efficiency

TRNAU1AP (tRNA selenocysteine associated protein (SECP43)) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a key player in the regulation of protein synthesis in eukaryotic cells and is involved in the structure and function of tRNAs, the small nuclear RNA molecules that carry amino acids from the cell's amino acid pool to the ribosome for protein synthesis.

One of the unique features of TRNAU1AP is its ability to interact with tRNAs and influence the stability and translation efficiency of these molecules. This interaction between TRNAU1AP and tRNAs makes it an attractive target for drug development.

TRNAU1AP is a member of the AP family of proteins, which includes a variety of proteins involved in the regulation of protein synthesis and dynamics. These proteins are characterized by a conserved catalytic core and a N-terminal region that is involved in the regulation of protein stability and interactions with other cellular components.

The function of TRNAU1AP is to regulate the translation of selenocysteine-containing tRNAs into the cytoplasm. Selenocysteine is a modified form of cysteine that is added to tRNAs by the 2-oxoglutarate-dependent cysteine synthase enzyme. The addition of selenocysteine to tRNAs is critical for their stability and translation efficiency, and TRNAU1AP is involved in this process.

In addition to its role in regulating tRNA stability, TRNAU1AP is also involved in the regulation of protein synthesis more broadly. It has been shown to interact with a variety of cellular components, including the ribosome, the cytoskeleton, and various enzymes involved in protein synthesis.

TRNAU1AP is also a potential biomarker for a variety of diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. Its involvement in the regulation of protein synthesis and the contribution it makes to the regulation of tRNA structure and function make it a valuable target for research and development.

TRNAU1AP is a promising drug target due to its involvement in the regulation of protein synthesis and its potential as a biomarker for a variety of diseases. Further research is needed to fully understand its function and its potential as a therapeutic target.

Protein Name: TRNA Selenocysteine 1 Associated Protein 1

Functions: Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis (By similarity)

The "TRNAU1AP Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRNAU1AP comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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