PRKAB2: A Mitochondrial Function Regulator and Potential Drug Target

Target Name: PRKAB2

NCBI ID: G5565

PRKAB2

PRKAB2: A Mitochondrial Function Regulator and Potential Drug Target

PRKAB2 (PRKAB2_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, lungs, and kidneys. It is a member of the PRKAB2 family, which includes several related proteins that play important roles in cellular signaling and inflammation. One of the most interesting aspects of PRKAB2 is its potential as a drug target or biomarker.

The PRKAB2 family is characterized by the presence of a single transmembrane domain and a highly conserved N-terminus. This conserved region is involved in several different functions, including cell signaling, protein-protein interactions, and inflammation. One of the most significant functions of PRKAB2 is its role in the regulation of mitochondrial function and energy metabolism.

Mitochondria are organelles that are responsible for generating the majority of the energy that is produced by cells. They are also involved in the regulation of various cellular processes, including metabolism, redox reactions, and signaling. PRKAB2 is highly conserved in its structure and function, which suggests that it plays an important role in these processes.

One of the most interesting functions of PRKAB2 is its role in the regulation of mitochondrial function and energy metabolism. PRKAB2 is known to interact with various cellular signaling pathways, including the TCA cycle, which is the central pathway of mitochondrial metabolism. This interaction suggests that PRKAB2 plays an important role in regulating the TCA cycle and the metabolism that is required for cellular growth and survival.

In addition to its role in cell signaling, PRKAB2 is also involved in the regulation of protein-protein interactions. This is important for the regulation of various cellular processes, including cell signaling, protein-protein interactions, and inflammation. One of the most interesting examples of PRKAB2's role in protein-protein interactions is its interaction with the protein Parkin, which is involved in the regulation of mitochondrial function.

PRKAB2 is also involved in the regulation of inflammation, which is a critical function for the immune system and for maintaining the health of the body. This is important for the regulation of various cellular processes, including cell signaling, protein-protein interactions, and inflammation. One of the most interesting examples of PRKAB2's role in inflammation is its interaction with the protein NF-kappa-B, which is involved in the regulation of inflammation and cellular signaling.

In conclusion, PRKAB2 is a protein that is highly conserved in its structure and function, and that plays an important role in the regulation of cell signaling, protein-protein interactions, and inflammation. Its potential as a drug target or biomarker makes it an attractive target for further research in the field of pharmaceuticals. Further studies are needed to understand the full range of functions of PRKAB2 and its potential as a drug.

Protein Name: Protein Kinase AMP-activated Non-catalytic Subunit Beta 2

Functions: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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