Pleckha7: A Protein with Potential as A Drug Target and Biomarker

Target Name: PLEKHA7

NCBI ID: G144100

PLEKHA7

Pleckha7: A Protein with Potential as A Drug Target and Biomarker

Pleckha7, also known as A7, is a protein that is located in the endoplasmic reticulum (ER) and plays a critical role in the regulation of protein stability and localization. It is made up of a domain containing homology with the protein pleckstrin, which is also known as A2. The pleckstrin domain is a small protein that is found in a variety of organisms and functions as a binding protein for various intracellular molecules.

One of the key functions of Pleckha7 is its role in the regulation of protein stability. It is known to interact with several different protein substrates and has been shown to play a role in the stability of a variety of proteins, including the protein tyrosine phosphatase (PTP) and the protein serine/thiosephosphate kinase (STK).

In addition to its role in protein stability, Pleckha7 is also involved in the regulation of protein localization. It has been shown to interact with the proteinBeclin-1 (BECN1), which is a protein that is involved in the regulation of cell adhesion. This interaction between Pleckha7 and Beclin-1 has been shown to play a role in the regulation of protein localization and stability.

Pleckha7 is also of interest as a potential drug target. Its role in the regulation of protein stability and localization makes it a potential target for small molecules that can modulate its activity. For example, drugs that inhibit the interaction between Pleckha7 and Beclin-1 may have therapeutic benefits in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Another potential application of Pleckha7 is as a biomarker. Its role in the regulation of protein stability and localization makes it a potential indicator of the health of cells. For example, decreased levels of Pleckha7 have been shown to be associated with the development of a variety of diseases, including cancer and neurodegenerative disorders.

In conclusion, Pleckha7 is a protein that is of interest as a potential drug target and biomarker. Its role in the regulation of protein stability and localization makes it a potential target for small molecules that can modulate its activity. Further research is needed to fully understand the role of Pleckha7 in the regulation of protein stability and localization, as well as its potential as a drug target and biomarker.

Protein Name: Pleckstrin Homology Domain Containing A7

Functions: Required for zonula adherens biogenesis and maintenance (PubMed:19041755). Acts via its interaction with CAMSAP3, which anchors microtubules at their minus-ends to zonula adherens, leading to the recruitment of KIFC3 kinesin to the junctional site (PubMed:19041755). Mediates docking of ADAM10 to zonula adherens through a PDZD11-dependent interaction with the ADAM10-binding protein TSPAN33 (PubMed:30463011)

The "PLEKHA7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLEKHA7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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