Pleckha6: A Protein Regulating The Blood-Brain Barrier and Cellular Signaling

Target Name: PLEKHA6

NCBI ID: G22874

PLEKHA6

Pleckha6: A Protein Regulating The Blood-Brain Barrier and Cellular Signaling

Pleckha6 (Pleckstrin homology domain containing A6) is a protein that is expressed in various tissues and cells in the human body. It is a member of the P protein family, which is a family of transmembrane proteins that contain a characteristic domain called Pleckstrin homology. This domain is composed of a stretch of amino acids that is similar to the beginning of the beta-sheet region of a protein, which is a common structural feature in proteins that is derived from the nucleotide sequence of DNA.

The P protein family is characterized by the presence of a variable region at the C-terminus of the protein, which is responsible for the protein's unique structure and function. The variable region includes a conserved catalytic core, which is responsible for the protein's enzymatic activity , as well as a variable region that is unique to each protein.

Pleckha6 is a 22-kDa protein that is expressed in the heart, liver, and pancreas. It is localized to the endoplasmic reticulum (ER), which is the protein synthesis and quality control organ of the cell. Pleckha6 is involved in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism.

One of the unique features of Pleckha6 is its role in the regulation of the blood-brain barrier (BBB), which is a specialized barrier that separates the brain from the bloodstream. The BBB is designed to allow certain molecules to enter the brain while keeping others out, which is important for maintaining the integrity of the brain and protecting it from harmful substances.

Pleckha6 is known to be involved in the regulation of the expression of genes in the brain, as well as in the transport of certain molecules across the BBB. It has been shown to play a role in the regulation of neurotransmitter synthesis and release, as well as in the regulation of ion channels in neuron cells.

In addition to its role in the BBB, Pleckha6 is also involved in the regulation of cellular signaling pathways. It has been shown to play a role in the regulation of the phosphorylation of various cellular signaling proteins, including casein kinase (CK) 2, which is involved in cell signaling and metabolism.

Pleckha6 is also involved in the regulation of cell division and apoptosis. It has been shown to play a role in the regulation of mitosis, as well as in the regulation of apoptosis, which is the process by which cells undergo programmed cell death.

In conclusion, Pleckha6 is a protein that is expressed in various tissues and cells in the human body. It is a member of the P protein family and is characterized by the presence of a variable region at the C-terminus of the protein. Pleckha6 is involved in various cellular processes, including the regulation of the blood-brain barrier, the regulation of neurotransmitter synthesis and release, and the regulation of cellular signaling pathways. It is also involved in the regulation of cell division and apoptosis. Given its unique structure and function, Pleckha6 is a potential drug target and may be useful in the development of new therapeutic strategies for various diseases.

Protein Name: Pleckstrin Homology Domain Containing A6

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