PLEKHA8: A Potential Drug Target and Biomarker (G84725)

Target Name: PLEKHA8

NCBI ID: G84725

PLEKHA8

PLEKHA8: A Potential Drug Target and Biomarker

Pleckstrin homology domain-containing family A member 8 (ISOform 1) is a protein that plays a crucial role in various cellular processes. It is characterized by the presence of a pleckstrin homology domain, which is a structural region that contains a nucleotide-binding oligomerization domain and a transmembrane region. PLEKHA8 is a member of the PLEKHA family, which is known for its role in regulating protein-protein interactions and signaling pathways.

The PLEKHA8 protein is involved in various cellular processes, including cell signaling, DNA replication, and cell survival. It is a key regulator of the Src/FAK-associated signaling pathway, which is involved in cell growth, differentiation, and survival. PLEKHA8 plays a vital role in the regulation of this pathway by interacting with the protein Src and the tyrosine kinase FAK.

Pleckstrin homology domains are characterized by the presence of a nucleotide-binding oligomerization domain, which is a structural region that binds to specific nucleotides. This domain is responsible for the interaction between the protein and its nucleotide ligands. The transmembrane region of PLEKHA8 is responsible for its ability to interact with the cytoplasmic environment and for its role in intracellular signaling.

Pleckstrin homology domains are found in various proteins, including neurotransmitter receptors, ion channels, and protein-protein interactions. They are also involved in various signaling pathways, including cell signaling, DNA replication, and cell survival. The PLEKHA8 protein is a potential drug target and biomarker due to its involvement in various cellular processes.

In addition to its role in cell signaling and DNA replication, PLEKHA8 is also involved in the regulation of cell survival. It has been shown to play a vital role in the regulation of cell apoptosis, which is a critical process that helps remove damaged or dysfunctional cells from the body. PLEKHA8 has been shown to regulate the expression of genes involved in cell apoptosis, including the Bcl-2 gene.

Pleckstrin homology domains have also been found to be involved in protein-protein interactions. The PLEKHA8 protein has been shown to interact with various proteins, including the protein Src and the tyrosine kinase FAK. These interactions are important for the regulation of various cellular processes, including cell signaling and DNA replication.

In conclusion, PLEKHA8 is a protein that plays a crucial role in various cellular processes. Its involvement in the regulation of cell signaling, DNA replication, and cell survival makes it a potential drug target and biomarker. The pleckstrin homology domain, transmembrane region, and nucleotide-binding oligomerization domain are significant features that contribute to PLEKHA8's role in cellular processes. Further research is needed to fully understand the mechanisms of PLEKHA8's role in cellular processes and its potential as a drug target and biomarker.

Protein Name: Pleckstrin Homology Domain Containing A8

Functions: Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation

The "PLEKHA8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLEKHA8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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