Target Name: AKNA
NCBI ID: G80709
Review Report on AKNA Target / Biomarker Content of Review Report on AKNA Target / Biomarker
AKNA
Other Name(s): B2 | Microtubule organization protein AKNA (isoform 1) | D | AT-hook transcription factor | AKNA variant 2 | AT-hook transcription factor AKNA | AT-hook-containing transcription factor | AKNA transcript F2 | Microtubule organization protein AKNA | RP11-82I1.4 | AKNA_HUMAN | KIAA1968 | AT-hook transcription factor, transcript variant 2

AKNA: A Key Enzyme in The Production of Many Compounds

AKNA (Alkylator Ketene Acetyltransferase) is a enzyme that is involved in the production of a variety of compounds, including drugs such as painkillers, anti-inflammatory agents, and personal care products. It is a key enzyme in the synthesis pathway of these compounds and is a potential drug target for several diseases.

The synthesis of many drugs requires the production of certain compounds, which are then modified and purified to produce the final product. AKNA is involved in this process and is a crucial enzyme in the production of these compounds. It is found in many organisms, including bacteria, fungi, and eukaryotes, and is involved in the production of a wide range of compounds, including:

* Alkylators, which are drugs that can cause tissue damage and are often used to treat pain and inflammation.
* Anesthetics, which are drugs that are used to treat anxiety and other conditions.
* Personal care products, such as shampoos and soap.
* Other compounds that are used in the production of pharmaceuticals, including painkillers and anti-inflammatory agents.

AKNA is a transmembrane protein that is located in the cytoplasm of cells. It is composed of a catalytic active site, a regulatory region, and a cytoplasmic region. The catalytic active site is the region where the enzyme performs its catalytic work, while the regulatory region is responsible for regulating the activity of the enzyme. The cytoplasmic region is responsible for the stability and localization of the enzyme.

The synthesis of AKNA is a complex process that involves several steps. The first step is the production of a precursor molecule, which is then transformed into the active enzyme through a series of intermediate steps. The second step is the catalytic reaction, which is the conversion of the precursor molecule to the active product. This reaction is the most critical step in the synthesis pathway and is the site where the enzyme performs its catalytic work.

AKNA is a potent enzyme that is involved in the production of a wide range of compounds. It is a potential drug target for several diseases, including cancer, pain, and inflammation. The inhibition of AKNA has been shown to be effective in treating several diseases, including cancer, and has the potential to be a valuable tool in the development of new treatments.

In addition to its potential as a drug target, AKNA is also a valuable biomarker for several diseases. The levels of AKNA can be used to assess the severity of disease in individuals and to monitor the effectiveness of treatments. The activity of AKNA can also be used to identify new potential drug targets and to study the mechanisms of disease.

Overall, AKNA is a fascinating enzyme that is involved in the production of a wide range of compounds. It is a potential drug target and a valuable biomarker for several diseases. Further research is needed to fully understand the role of AKNA in the synthesis pathway and to develop new treatments based on its inhibition.

Protein Name: AT-hook Transcription Factor

Functions: Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidences are required to reconcile these two apparently contradictory functions (Probable)

The "AKNA Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AKNA comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

AKNAD1 | AKR1A1 | AKR1B1 | AKR1B10 | AKR1B10P1 | AKR1B15 | AKR1C1 | AKR1C2 | AKR1C3 | AKR1C4 | AKR1C6P | AKR1C8 | AKR1D1 | AKR1E2 | AKR7A2 | AKR7A2P1 | AKR7A3 | AKR7L | AKT1 | AKT1S1 | AKT2 | AKT3 | AKTIP | ALAD | ALAS1 | ALAS2 | ALB | ALCAM | Alcohol Dehydrogenase | Alcohol dehydrogenase Class 1 | Aldehyde Dehydrogenase | ALDH16A1 | ALDH18A1 | ALDH1A1 | ALDH1A2 | ALDH1A3 | ALDH1A3-AS1 | ALDH1B1 | ALDH1L1 | ALDH1L1-AS1 | ALDH1L2 | ALDH2 | ALDH3A1 | ALDH3A2 | ALDH3B1 | ALDH3B2 | ALDH4A1 | ALDH5A1 | ALDH6A1 | ALDH7A1 | ALDH8A1 | ALDH9A1 | Aldo-Keto Reductase Family 1 | ALDOA | ALDOAP2 | ALDOB | ALDOC | ALG1 | ALG10 | ALG10B | ALG11 | ALG12 | ALG13 | ALG14 | ALG1L10P | ALG1L13P | ALG1L1P | ALG1L2 | ALG1L5P | ALG1L7P | ALG1L8P | ALG2 | ALG3 | ALG5 | ALG6 | ALG8 | ALG9 | ALK | ALKAL1 | ALKAL2 | Alkaline Phosphatase (ALP) | ALKBH1 | ALKBH2 | ALKBH3 | ALKBH4 | ALKBH5 | ALKBH6 | ALKBH7 | ALKBH8 | ALLC | ALMS1 | ALMS1-IT1 | ALMS1P1 | ALOX12 | ALOX12-AS1 | ALOX12B | ALOX12P2 | ALOX15 | ALOX15B | ALOX15P1