AKAP10: A protein kinase A anchoring protein, potential drug target and biomarker

Target Name: AKAP10

NCBI ID: G11216

AKAP10

AKAP10: A protein kinase A anchoring protein, potential drug target and biomarker

Protein kinase A (PKA) is a ubiquitously expressed protein that plays a crucial role in various cellular processes, including cell signaling, DNA replication, and chromatin remodeling. PIKAs are divided into three subfamilies based on their catalytic mechanism, subunit, and anchoring protein properties. The anchoring protein 10 (AKAP10) is a member of the subfamily 2, which is characterized by the presence of a long N-terminus and a unique N-terminal domain that contains a GFP-like fluorescent tag.

The AKAP10 protein is a 21 kDa protein that is expressed in various tissues and cell types, including muscle, heart, brain, and cancer cells. It is highly anchored to the endoplasmic reticulum (ER) and localizes to the cytoplasm, where it can interact with various protein substrates. The protein has been shown to play a critical role in cell signaling, and its expression levels have been associated with various diseases, including cancer.

Potential drug targets and biomarkers

The AKAP10 protein is a potential drug target due to its unique anchoring property, which allows it to interact with various protein substrates in the ER. This interaction may provide a novel mechanism for targeting proteins that are misfolded or have altered levels of expression levels.

One of the potential drug targets for AKAP10 is protein kinases that are involved in cell signaling pathways. These kinases can be either activating or inhibiting, and their activity can be modulated by AKAP10. For example, the activity of the protein serine/threonine kinase (PTK) can be inhibited by AKAP10, which may be a useful strategy for targeting mutated or hyperactive PTKs.

Another potential drug target for AKAP10 is the protein Aurora, which is involved in the regulation of mitochondrial dynamics. Aurora is a G-protein-coupled receptor that can modulate mitochondrial function and contribute to various diseases, including cancer. The activity of Aurora can be modulated by AKAP10, which may be a targetable intervention for the treatment of these diseases.

In addition to these potential drug targets, AKAP10 has also been shown to be a potential biomarker for various diseases, including cancer. The expression of AKAP10 has been shown to be elevated in various types of cancer, including breast, lung, and ovarian cancer. This may suggest that AKAP10 could be a useful biomarker for the diagnosis and monitoring of cancer.

Conclusion

In conclusion, the AKAP10 protein is a unique and highly anchored protein that plays a critical role in various cellular processes. Its expression levels have been associated with various diseases, including cancer, and its activity can be modulated by various drug targets. Therefore, AKAP10 may be a potential drug target and biomarker for the treatment of various diseases. Further research is needed to fully understand the role of AKAP10 in cellular signaling and its potential as a drug and biomarker.

Protein Name: A-kinase Anchoring Protein 10

Functions: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity)

The "AKAP10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AKAP10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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