Role of AK8 in Cell Signaling and Its Potential Therapeutic Applications

Target Name: AK8

NCBI ID: G158067

Content of Review Report on AK8 Target / Biomarker

AK8

Role of AK8 in Cell Signaling and Its Potential Therapeutic Applications

AK8 (ATP-AMP transphosphorylase 8) is a protein that is expressed in various tissues and cells throughout the body. It plays a crucial role in the regulation of cell signaling pathways, particularly in the process of cell signaling via theAMP (adenylyl cyclic AMP) signaling pathway. AK8 has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

The Role of AK8 in Cell Signaling

AK8 is a key enzyme in the process of AMP signaling, which is a critical pathway involved in various cellular processes, including cell signaling, protein synthesis, and inflammation. AMP is a highly responsive signaling molecule that plays a crucial role in the regulation of cellular processes, including the regulation of gene expression, protein synthesis, and cell signaling.

AK8 is involved in the process of AMP-dependent phosphorylation, that is, the phosphorylation of AMP and ADP, thereby generating cell signaling. In addition, AK8 is also the prosthetic group of AMP and ADP phosphorylase. AMP phosphorylase is an important enzyme responsible for catalyzing the phosphorylation reaction between AMP and ADP to generate cell signals.

Expression and Function of AK8

AK8 is highly expressed in various tissues and cells, including muscle, heart, brain, and cancer cells. It is also involved in the regulation of cellular processes, including cell signaling, protein synthesis, and inflammation.

In addition to its role in AMP signaling, AK8 is also involved in the regulation of cellular processes that are independent of AMP signaling, such as cell adhesion, migration, and invasion. It is also involved in the regulation of cellular processes that are dependent on AMP signaling, such as the regulation of cell signaling pathways that are dependent on AMP signaling, including the regulation of angiogenesis, inflammation, and tissue repair.

Potential Therapeutic Applications of AK8

The therapeutic potential applications of AK8 are vast and varied. As a drug target, AK8 has been identified as a potential therapeutic target for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases.

In the context of cancer, AK8 has been identified as a potential therapeutic target for various types of cancer, including breast cancer, lung cancer, and colorectal cancer. Studies have shown that inhibition of AK8 has the potential to enhance the effectiveness of various chemotherapy treatments , including those that target DNA repair and cell cycle inhibitors.

In the context of neurodegenerative diseases, AK8 has been identified as a potential therapeutic target for diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. Studies have shown that inhibition of AK8 has the potential to enhance the effectiveness of various neurodegenerative disease treatments, including those that target neurotransmitter synthesis and degradation.

In the context of cardiovascular diseases, AK8 has been identified as a potential therapeutic target for diseases such as hypertension, heart failure, and myocardial infarction. Studies have shown that inhibition of AK8 has the potential to enhance the effectiveness of various cardiovascular disease treatments, including those that target blood pressure, heart rate, and blood flow.

Conclusion

In conclusion, AK8 is a protein that plays a crucial role in the regulation of cell signaling pathways, particularly in the process of cell signaling via theAMP (adenylyl cyclic AMP) signaling pathway. Its expression is highly variable in various tissues and cells throughout the body , and it has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Further research is needed to fully understand the role of AK8 in cellular processes and its potential therapeutic applications.

Protein Name: Adenylate Kinase 8

Functions: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity

The "AK8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AK8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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