AKAP8: A Potential Drug Target and Biomarker (G10270)

Target Name: AKAP8

NCBI ID: G10270

AKAP8

AKAP8: A Potential Drug Target and Biomarker

AKAP8, or A-kinase anchor protein 8, is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. Its unique structure and function have made it an attractive target for researchers to study, and its potential as a drug or biomarker has gained significant interest in the scientific community.

The A-kinase anchor protein 8 (AKAP8) is a protein that is expressed in various cell types, including neurons, glial cells, and blood vessels. It is a member of the A-kinase anchor protein family, which is a subfamily of the protein tyrosine kinase family. This family is known for its role in cell signaling and protein-protein interactions, and the AKAP8 protein is involved in several signaling pathways, including the regulation of cell adhesion, migration, and survival.

One of the key features of AKAP8 is its ability to interact with various signaling molecules, including tyrosine kinases, phosphatidylinositol (PI)3-kinases, and serine/thionyl hydrazine (SH) stress-inducible protein (SHIP). These interactions allow the protein to play a role in the regulation of cellular processes that are important for the development and progression of various diseases.

In addition to its role in cell signaling, AKAP8 has also been shown to be involved in the regulation of cellular mechanics and the maintenance of cellular organization. Its ability to interact with cytoskeletal components, such as actin and microtubules, suggests that it may be involved in the regulation of cell shape and movement. Additionally, studies have shown that AKAP8 is involved in the regulation of cell adhesion, which is important for the development of tissues and organs and is often disrupted in diseases such as cancer.

The potential drug target for AKAP8 is its role in cell signaling and its involvement in the regulation of cellular mechanics. Drugs that target AKAP8 have the potential to treat various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. For example, studies have shown that inhibiting the activity of AKAP8 can lead to the growth arrest and apoptosis (programmed cell death) of cancer cells, and that this effect is dependent on the expression level of the protein. Additionally, drugs that target AKAP8 have been shown to be effective in treating neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, by modulating the activity of AKAP8 and other signaling molecules.

In addition to its potential as a drug target, AKAP8 has also been identified as a potential biomarker for various diseases. The protein is expressed in various tissues and cells, including brain, spleen, and peripheral blood, and its levels can be affected by a variety of factors, including disease, nutrition, and environmental conditions. Studies have shown that the levels of AKAP8 can be affected by factors such as cancer, neurodegenerative diseases, and psychiatric disorders, and that these changes in levels may be associated with the development and progression of these diseases. Additionally, the regulation of AKAP8 levels has been shown to be involved in the development and progression of various psychiatric disorders, such as depression and anxiety.

In conclusion, AKAP8 is a protein that has significant potential as a drug target and biomarker for various diseases. Its unique structure and function, as well as its ability to interact with various signaling molecules, make it an attractive target for researchers to study. Further studies are needed to fully understand the role of AKAP8 in the regulation of cellular processes and its potential as a drug or biomarker.

Protein Name: A-kinase Anchoring Protein 8

Functions: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). May play a repressive role in the regulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro. In cells, associates with ribosomal RNA (rRNA) chromatin, preferentially with rRNA promoter and transcribed regions (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation; the function probably implicates targeting of PKA to NFKB1 (By similarity)

The "AKAP8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about AKAP8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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