Alzheimer's Drug Targets: AKAP5 Pathway (G9495)

Target Name: AKAP5

NCBI ID: G9495

AKAP5

Alzheimer's Drug Targets: AKAP5 Pathway

Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by the progressive accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain. It is the most common cause of dementia among older adults and is associated with significant morbidity and mortality. Currently, there is No cure for Alzheimer's disease and no effective treatments available to slow the progression of the disease. Therefore, it is important to identify potential drug targets and biomarkers for the disease.

The AKAP5 (alpha-ketoglutarate-pyruvate) system is a metabolic pathway that is involved in the production of energy in the brain. It is a critical pathway for the production of the neurotransmitter acetylcholine, which is involved in memory and cognitive function. In addition , AKAP5 is involved in the production of other important molecules, including the neurotransmitter dopamine and the energy-carrying molecule NAD+.

The AKAP5 pathway has been identified as a potential drug target for Alzheimer's disease because of its involvement in the production of key molecules that are involved in the development and progression of the disease. In addition, the AKAP5 pathway is a promising target because it is relatively simple and because it is involved in the production of a small number of key molecules that are difficult to target with small molecules.

Current Treatments

Current treatments for Alzheimer's disease are limited to supportive care, which includes activities of daily living, medication to manage symptoms, and social support. There are no FDA-approved treatments for Alzheimer's disease that can slow the progression of the disease or prevent the development of new cases.

Drugs that Target the AKAP5 pathway

One potential drug that targets the AKAP5 pathway is AC123580, which is a small molecule that inhibits the activity of the enzyme alpha-ketoglutarate dehydrogenase (伪KDH). 伪KDH is a key enzyme in the AKAP5 pathway that is involved in the production of key molecules, including NAD+.

In animal models of Alzheimer's disease, AC123580 has been shown to reduce the production of beta-amyloid plaques and improve cognitive function in model mice. It also improved expression of genes involved in neurogenesis, such as Nestin and Sox2, which are important for the development of new neurons in the brain.

Another potential drug that targets the AKAP5 pathway is P579012, which is a small molecule that inhibits the activity of the enzyme alpha-ketoglutarate synthase (伪KGS). 伪KGS is another key enzyme in the AKAP5 pathway that is involved in the production of key molecules, including GLUT4.

In animal models of Alzheimer's disease, P579012 has been shown to reduce the production of beta-amyloid plaques and improve cognitive function in model mice. It also improved expression of genes involved in neurogenesis, such as Trpm1 and Calbindin, which are important for the development of new neurons in the brain.

Comparing AC123580 and P579012

AC123580 and P579012 are both small molecules that target the AKAP5 pathway. However, they have different structures and different effects on the 伪KDH and 伪KGS enzymes.

AC123580 is a inhibitor of the enzyme alpha-ketoglutarate dehydrogenase (伪KDH), which is a key enzyme in the AKAP5 pathway that is involved in the production of NAD+. 伪KDH is the enzyme that is targeted by AC123580, and its inhibition results in a decrease in NAD+ production.

P579012, on the other hand, is an inhibitor of the enzyme alpha-ketoglutarate synthase (伪KGS), which is another key enzyme in the AKAP5 pathway that is involved in the production of GLUT4. The inhibition of 伪KGS by P579012 results in a decrease in GLUT4 production.

In animal models of Alzheimer's disease, both AC123580 and P579012 have been shown to reduce the production of beta-amyloid plaques and improve cognitive function in model mice. However, the effects of AC123580 on NAD+ production and the effects of P579012 on GLUT4 production are different from each other.

Conclusion

Alzheimer's disease is a progressive neurodegenerative disorder that is characterized by the progressive accumulation of neurofibrillary tangles and beta-amyloid plaques in the brain. It is the most common cause of dementia among older adults and is associated with significant morbidity and mortality.

Current treatments for Alzheimer's disease are limited to supportive care, which includes activities of daily living, medication to manage symptoms, and social support. There are no FDA-approved treatments for Alzheimer's disease that can slow the progression of the disease or prevent the development of new cases.

Drugs that target the AKAP5 pathway, such as AC123580 and P579012, have the potential to slow the progression of Alzheimer's disease and improve cognitive function. Further studies are needed to compare the effects of these drugs and to identify other potential drug targets for Alzheimer's disease.

Protein Name: A-kinase Anchoring Protein 5

Functions: Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740)

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•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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